The burden attributable to mental and substance use disorders as risk factors for suicide : findings from the Global Burden of Disease Study 2010


Autoria(s): Ferrari, Alize J.; Norman, Rosana E.; Freedman, Greg D.; Baxter, Amanda J.; Pirkis, Jane E.; Harris, Meredith G.; Page, Andrew; Carnahan, Emily; Degenhardt, Louisa; Vos, Theo; Whiteford, Harvey A.
Data(s)

2014

Resumo

Background The Global Burden of Disease Study 2010 (GBD 2010) identified mental and substance use disorders as the 5th leading contributor of burden in 2010, measured by disability adjusted life years (DALYs). This estimate was incomplete as it excluded burden resulting from the increased risk of suicide captured elsewhere in GBD 2010's mutually exclusive list of diseases and injuries. Here, we estimate suicide DALYs attributable to mental and substance use disorders. Methods Relative-risk estimates of suicide due to mental and substance use disorders and the global prevalence of each disorder were used to estimate population attributable fractions. These were adjusted for global differences in the proportion of suicide due to mental and substance use disorders compared to other causes then multiplied by suicide DALYs reported in GBD 2010 to estimate attributable DALYs (with 95% uncertainty). Results Mental and substance use disorders were responsible for 22.5 million (14.8-29.8 million) of the 36.2 million (26.5-44.3 million) DALYs allocated to suicide in 2010. Depression was responsible for the largest proportion of suicide DALYs (46.1% (28.0%-60.8%)) and anorexia nervosa the lowest (0.2% (0.02%-0.5%)). DALYs occurred throughout the lifespan, with the largest proportion found in Eastern Europe and Asia, and males aged 20-30 years. The inclusion of attributable suicide DALYs would have increased the overall burden of mental and substance use disorders (assigned to them in GBD 2010 as a direct cause) from 7.4% (6.2%-8.6%) to 8.3% (7.1%-9.6%) of global DALYs, and would have changed the global ranking from 5th to 3rd leading cause of burden. Conclusions Capturing the suicide burden attributable to mental and substance use disorders allows for more accurate estimates of burden. More consideration needs to be given to interventions targeted to populations with, or at risk for, mental and substance use disorders as an effective strategy for suicide prevention.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/79828/

Publicador

Public Library of Science

Relação

http://eprints.qut.edu.au/79828/1/Ferrari%20Suicide%20PLoS%20ONE.pdf

DOI:10.1371/journal.pone.0091936

Ferrari, Alize J., Norman, Rosana E., Freedman, Greg D., Baxter, Amanda J., Pirkis, Jane E., Harris, Meredith G., Page, Andrew, Carnahan, Emily, Degenhardt, Louisa, Vos, Theo, & Whiteford, Harvey A. (2014) The burden attributable to mental and substance use disorders as risk factors for suicide : findings from the Global Burden of Disease Study 2010. PLoS ONE, 9(4), e91936.

Direitos

Copyright 2014 Ferrari et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Fonte

Faculty of Health; Institute of Health and Biomedical Innovation; School of Public Health & Social Work

Palavras-Chave #110000 MEDICAL AND HEALTH SCIENCES #111700 PUBLIC HEALTH AND HEALTH SERVICES #111706 Epidemiology #111714 Mental Health #age distribution #anorexia nervosa #article #Asia #attributable risk #depression #disability #disability adjusted life year #disease association #Eastern Europe #gender #human #lifespan #mental disease #prevalence #risk factor #substance abuse #suicide
Tipo

Journal Article