Longitudinal performance of polycaprolactone-based scaffold plus recombinant human morphogenetic protein-2 (rhBMP-2) in large preclinical animal model : 6- versus 12 months
Contribuinte(s) |
Raso, James Aubin, Carl-Eric |
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Data(s) |
02/07/2014
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Resumo |
There is strong current interest in the use of biodegradable scaffolds in combination with bone growth factors as a valuable alternative to the current gold standard autograft in spinal fusion surgery Yong et al. (2013). Here we report on 6- vs 12- month data set evaluating the longitudinal performance of a CaP coated polycaprolactone (PCL) scaffold loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2) as a bone graft substitute within a preclinical ovine thoracic spine. The results of this study demonstrate the efficacy of scaffold-based delivery of rhBMP-2 in promoting higher fusion grades at 6- and 12- months in comparison to the scaffold alone or autograft group within the same time frame. Fusion grades achieved at six months using PCL+rhBMP-2 are not significantly increased at twelve months post surgery. |
Formato |
application/pdf application/pdf |
Identificador | |
Publicador |
BioMed Central |
Relação |
http://eprints.qut.edu.au/79636/1/YONG%20IRSSD%20-%20ePrints.pdf http://eprints.qut.edu.au/79636/8/__staffhome.qut.edu.au_staffgrouph%24_hollambc_Desktop_1748-7161-10-S1-O58.pdf http://www.scoliosisjournal.com/content/10/S1/O58 DOI:10.1186/1748-7161-10-S1-O58 Yong, Mostyn R., Savi, Flavia M., Woodruff, Maria A., Saifzadeh, Siamak, Askin, Geoffrey N., Labrom, Robert D., Hutmacher, Dietmar, & Adam, Clayton J. (2014) Longitudinal performance of polycaprolactone-based scaffold plus recombinant human morphogenetic protein-2 (rhBMP-2) in large preclinical animal model : 6- versus 12 months. In Raso, James & Aubin, Carl-Eric (Eds.) The 10th Meeting of the International Research Society of Spinal Deformities (IRSSD 2014), 29 June - 2 July 2014, Sapporo, Japan. |
Direitos |
Copyright 2015 Yong et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Fonte |
School of Chemistry, Physics & Mechanical Engineering; Institute of Health and Biomedical Innovation; Science & Engineering Faculty |
Palavras-Chave | #090302 Biomechanical Engineering #110314 Orthopaedics #animal model #spinal fusion #polycaprolactone #growth factors #bone tissue engineering |
Tipo |
Conference Item |