γ-radiation-induced γH2AX formation occurs preferentially in actively transcribing euchromatic loci
Data(s) |
01/01/2010
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Resumo |
The central dogma in radiation biology is that nuclear DNA is the critical target with respect to radiosensitivity. In accordance with the theoretical expectations, and in the absence of a conclusive model, the general consensus in the field has been to view chromatin as a homogeneous template for DNA damage and repair. This paradigm has been called into question by recent findings indicating a disparity in γ-irradiation-induced γH2AX foci formation in euchromatin and heterochromatin. Here, we have extended those studies and provide evidence that γH2AX foci form preferentially in actively transcribing euchromatin following γ-irradiation. |
Identificador | |
Publicador |
Birkhaeuser Science, Switzerland |
Relação |
DOI:10.1007/s00018-009-0181-5 Vasireddy, Raja S., Karagiannis, Tom C., & El-Osta, Assam (2010) γ-radiation-induced γH2AX formation occurs preferentially in actively transcribing euchromatic loci. Cellular and Molecular Life Sciences, 67(2), pp. 291-294. |
Fonte |
Faculty of Health |
Palavras-Chave | #111200 ONCOLOGY AND CARCINOGENESIS #Euchromatin #Heterochromatin #Histone methylation #γH2AX #Double strand break #γ-Radiation |
Tipo |
Journal Article |