Development and characterization of a novel, antimicrobial, sterile hydrogel dressing for burn wounds : single-step production with gamma irradiation creates silver nanoparticles and radical polymerization


Autoria(s): Boonkaew, Benjawan; Barber, Philip; Rengpipat, Sirirat; Supaphol, Pitt; Kempf, Margit; He, Jibao; John, Vijay; Cuttle, Leila
Data(s)

01/10/2014

Resumo

Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na(+) ) hydrogel. Silver nitrate was dissolved in AMPS-Na(+) solution and then exposed to gamma irradiation to form SNP-infused hydrogels. The gamma irradiation results in a cross-linked polymeric network of sterile hydrogel dressing and a reduction of silver ions to form SNPs infused in the hydrogel in a one-step process. About 80% of the total silver was released from the hydrogels after 72 h immersion in simulated body fluid solution; therefore, they could be used on wounds for up to 3 days. All the hydrogels were found to be nontoxic to normal human dermal fibroblast cells. The silver-loaded hydrogels had good inhibitory action against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Results from a pilot study on a porcine burn model showed that the 5-mM silver hydrogel was efficient at preventing bacterial colonization of wounds, and the results were comparable to the commercially available silver dressings (Acticoat(TM) , PolyMem Silver(®) ). These results support its use as a potential burn wound dressing.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/77862/

Publicador

John WIley & Sons Inc

Relação

http://eprints.qut.edu.au/77862/2/77862.pdf

DOI:10.1002/jps.24095

Boonkaew, Benjawan, Barber, Philip, Rengpipat, Sirirat, Supaphol, Pitt, Kempf, Margit, He, Jibao, John, Vijay, & Cuttle, Leila (2014) Development and characterization of a novel, antimicrobial, sterile hydrogel dressing for burn wounds : single-step production with gamma irradiation creates silver nanoparticles and radical polymerization. Journal of Pharmaceutical Sciences, 103(10), pp. 3244-3253.

Direitos

Copyright 2014 Wiley Periodicals, Inc. and the American Pharmacists Association

Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation

Tipo

Journal Article