Ecionines A and B, two new cytotoxic pyridoacridine alkaloids from the Australian marine sponge, Ecionemia geodides


Autoria(s): Barnes, Emma C.; Said, Nur Akmarina B.M.; Williams, Elizabeth D.; Hooper, John N.A.; Davis, Rohan A.
Data(s)

2010

Resumo

Chemical investigations of the Australian marine sponge Ecionemia geodides resulted in the isolation of two new pyridoacridine alkaloids, ecionines A (1) and B (2), along with the previously isolated marine natural products, biemnadin (3) and meridine (4). Compounds 1 and 2 both contain an imine moiety, which is rare for the pyridoacridine structure class. The chemical structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. All compounds were tested against a panel of human bladder cancer cell lines, the increasingly metastatic TSU-Pr1 series (TSU-Pr1, TSU-Pr1-B1 and TSU-Pr1- B2) and the superficial bladder cancer cell line 5637. Ecionine A (1) displayed cytotoxicity against all cell lines, with IC50 values ranging from 3 to 7 mM. This is the first report of chemistry from the sponge genus Ecionemia.

Identificador

http://eprints.qut.edu.au/77744/

Publicador

Elsevier

Relação

DOI:10.1016/j.tet.2009.10.109

Barnes, Emma C., Said, Nur Akmarina B.M., Williams, Elizabeth D., Hooper, John N.A., & Davis, Rohan A. (2010) Ecionines A and B, two new cytotoxic pyridoacridine alkaloids from the Australian marine sponge, Ecionemia geodides. Tetrahedron, 66(1), pp. 283-287.

Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation

Palavras-Chave #111201 Cancer Cell Biology #111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) #ecionines #bladder cancer #cytotoxic pyridoacridine alkaloids #Australian marine sponge #marine natural products
Tipo

Journal Article