Colloidal drug probe : Method development and validation for adhesion force measurement using Atomic Force Microscopy
Data(s) |
05/07/2014
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Resumo |
This study demonstrates a novel technique of preparing drug colloid probes to determine the adhesion force between a model drug salbutamol sulphate (SS) and the surfaces of polymer microparticles to be used as carriers for the dispersion of drug particles from dry powder inhaler (DPI) formulations. Model silica probes of approximately 4 lm size, similar to a drug particle used in DPI formulations, were coated with a saturated SS solution with the aid of capillary forces acting between the silica probe and the drug solution. The developed method of ensuring a smooth and uniform layer of SS on the silica probe was validated using X-ray Photoelectron Spectroscopy (XPS) and Scanning Electron Microscopy (SEM). Using the same technique, silica microspheres pre-attached on the AFM cantilever were coated with SS. The adhesion forces between the silica probe and drug coated silica (drug probe) and polymer surfaces (hydrophilic and hydrophobic) were determined. Our experimental results showed that the technique for preparing the drug probe was robust and can be used to determine the adhesion force between hydrophilic/ hydrophobic drug probe and carrier surfaces to gain a better understanding on drug carrier adhesion forces in DPI formulations. |
Identificador | |
Publicador |
Elsevier B.V. |
Relação |
http://ac.els-cdn.com/S0921883114001794/1-s2.0-S0921883114001794-main.pdf?_tid=28438c42-54d1-11e4-9f67-00000aab0f27&acdnat=1413421983_90d17e2beb017c1d7e31e7d64b2c9391 DOI:10.1016/j.apt.2014.06.021 Islam, Nazrul, Tuli, Rinku A., George, Graeme A., & Dargaville, Tim R. (2014) Colloidal drug probe : Method development and validation for adhesion force measurement using Atomic Force Microscopy. Advanced Powder Technology, 25, pp. 1240-1248. |
Direitos |
Coyright 2014 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved. Author's Pre-print: author can archive pre-print (ie pre-refereeing) Author's Post-print: author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: author cannot archive publisher's version/PDF |
Fonte |
School of Biomedical Sciences; School of Chemistry, Physics & Mechanical Engineering; School of Clinical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation; Science & Engineering Faculty |
Palavras-Chave | #030603 Colloid and Surface Chemistry #111504 Pharmaceutical Sciences #Pharmaceutical Sciences (111504) #Colloid and Surface Chemistry (030603) |
Tipo |
Journal Article |