Physical mechanism of the compressive response of F-actin networks : significance of crosslinker unbinding events
Data(s) |
23/06/2014
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Resumo |
A model of crosslinker unbinding is implemented in a highly coarsegrained granular model of F-actin cytoskeleton. We employ this specific granular model to study the mechanisms of the compressive responses of F-actin networks. It is found that the compressive response of F-actin cytoskeleton has dependency on the strain rate. The evolution of deformation energy in the network indicates that crosslinker unbinding events can induce the remodelling of F-actin cytoskeleton in response to external loadings. The internal stress in F-actin cytoskeleton can efficiently dissipate with the help of crosslinker unbinding, which could lead to the spontaneous relaxation of living cells. |
Formato |
application/pdf |
Identificador | |
Publicador |
American Institute of Physics |
Relação |
http://eprints.qut.edu.au/77645/1/Physical_mechanism_of_the_compressive_response_of_F-actinnetworks%EF%BC%9Asignificance_of_crosslinker_unbinding_events.pdf DOI:10.1063/2.1405106 Li, Tong, Hu, Dean, Yarlagadda, Prasad K., & Gu, YuanTong (2014) Physical mechanism of the compressive response of F-actin networks : significance of crosslinker unbinding events. Theoretical and Applied Mechanics Letters, 4(5), 051006-1. http://purl.org/au-research/grants/ARC/FT100100172 |
Direitos |
Copyright 2014 American Institute of Physics |
Fonte |
School of Chemistry, Physics & Mechanical Engineering; Science & Engineering Faculty |
Palavras-Chave | #029901 Biological Physics #091307 Numerical Modelling and Mechanical Characterisation #F-actin cytoskeleton #coarse-grained #crosslinker unbinding #compressive response |
Tipo |
Journal Article |