Stop-signal response inhibition in schizophrenia : Behavioural, event-related potential and functional neuroimaging data
| Data(s) |
01/01/2012
|
|---|---|
| Resumo |
Inhibitory control deficits are well documented in schizophrenia, supported by impairment in an established measure of response inhibition, the stop-signal reaction time (SSRT). We investigated the neural basis of this impairment by comparing schizophrenia patients and controls matched for age, sex and education on behavioural, functional magnetic resonance imaging (fMRI) and event-related potential (ERP) indices of stop-signal task performance. Compared to controls, patients exhibited slower SSRT and reduced right inferior frontal gyrus (rIFG) activation, but rIFG activation correlated with SSRT in both groups. Go stimulus and stop-signal ERP components (N1/P3) were smaller in patients, but the peak latencies of stop-signal N1 and P3 were also delayed in patients, indicating impairment early in stop-signal processing. Additionally, response-locked lateralised readiness potentials indicated response preparation was prolonged in patients. An inability to engage rIFG may predicate slowed inhibition in patients, however multiple spatiotemporal irregularities in the networks underpinning stop-signal task performance may contribute to this deficit. |
| Identificador | |
| Publicador |
Elseiver BV |
| Relação |
DOI:10.1016/j.biopsycho.2011.10.013 Hughes, Matthew Edward, Fulham, William Ross, Johnston, Patrick James, & Michie, Patricia Therese (2012) Stop-signal response inhibition in schizophrenia : Behavioural, event-related potential and functional neuroimaging data. Biological Psychology, 89(1), pp. 220-231. |
| Direitos |
Copyright 2012 Elsevier This is the author’s version of a work that was accepted for publication in Biological Psychology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biological Psychology, [VOL 89, ISSUE 1, (2012)] DOI: 10.1016/j.biopsycho.2011.10.013 |
| Fonte |
Faculty of Health; School of Psychology & Counselling |
| Palavras-Chave | #170101 Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology) #170112 Sensory Processes Perception and Performance #schizophrenia #response inhibition #ERPs #fMRI #stop-signal task #SSRT |
| Tipo |
Journal Article |
