Activation of toxic chemicals by cytochrome P450 enzymes : regio- and stereoselective oxidation of aflatoxin B1


Autoria(s): Guengerich, F. P.; Ueng, Y. F.; Kim, B. R.; Langouet, S.; Coles, B.; Iyer, R. S.; Thier, R.; Harris, T. M.; Shimada, T.; Yamazaki, H.; Ketterer, B.; Guillouzo, A.
Data(s)

1996

Resumo

Cytochrome P450 (P450) enzymes are involved in the oxidations of numerous steroids, eicosanoids, alkaloids, and other endogenous substrates. These enzymes are also the major ones involved in the oxidation of potential toxicants and carcinogens such as those encountered among pollutants, solvents, and pesticides, as well as many natural products. A proper understanding of the basic mechanisms by which the P450 enzymes oxidize such compounds is important in developing rational strategies for the evaluation of the risks of these compounds.

Identificador

http://eprints.qut.edu.au/77457/

Publicador

Springer New York LLC

Relação

http://link.springer.com/chapter/10.1007/978-1-4757-9480-9_2

Guengerich, F. P., Ueng, Y. F., Kim, B. R., Langouet, S., Coles, B., Iyer, R. S., Thier, R., Harris, T. M., Shimada, T., Yamazaki, H., Ketterer, B., & Guillouzo, A. (1996) Activation of toxic chemicals by cytochrome P450 enzymes : regio- and stereoselective oxidation of aflatoxin B1. Advances in Experimental Medicine and Biology, 387, pp. 7-15.

Direitos

Copyright 1996 Springer New York LLC

Fonte

School of Clinical Sciences; Faculty of Health

Palavras-Chave #3 methylcholanthrene #aflatoxin b1 #alpha naphthoflavone #cytochrome p450 #epoxide #oltipraz #conference paper #epoxidation #genotoxicity #human #human cell #liver cell #liver microsome #metabolic activation #oxidation #priority journal #stereoisomerism #Animals #Biotransformation #Cytochrome P-450 Enzyme System #Humans #Mutagens #Oxidation-Reduction
Tipo

Journal Article