The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory
| Data(s) |
01/08/2011
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| Resumo |
MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory. |
| Formato |
application/pdf |
| Identificador | |
| Publicador |
Nature Publishing Group |
| Relação |
http://eprints.qut.edu.au/75090/1/Nat_Neurosci_2011_Lin.pdf DOI:10.1038/nn.2891 Lin, Quan, Wei, Wei, Coelho, Carlos M, Li, Xiang, Baker-Andresen, Danay, Dudley, Kevin, Ratnu, Vikram S, Boskovic, Zoran, Kobor, Michael S, Sun, Yi E, & Bredy, Timothy W (2011) The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory. Nature Neuroscience, 14(9), pp. 1115-1117. |
| Direitos |
Copyright 2011 Nature Publishing Group |
| Fonte |
School of Earth, Environmental & Biological Sciences; Institute for Future Environments; Science & Engineering Faculty |
| Palavras-Chave | #060000 BIOLOGICAL SCIENCES #060404 Epigenetics (incl. Genome Methylation and Epigenomics) |
| Tipo |
Journal Article |
