Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates


Autoria(s): Suryadinata, Randy; Sadowski, Martin; Sarcevic, Boris
Data(s)

2010

Resumo

The eukaryotic cell cycle is a fundamental evolutionarily conserved process that regulates cell division from simple unicellular organisms, such as yeast, through to higher multicellular organisms, such as humans. The cell cycle comprises several phases, including the S-phase (DNA synthesis phase) and M-phase (mitotic phase). During S-phase, the genetic material is replicated, and is then segregated into two identical daughter cells following mitotic M-phase and cytokinesis. The S- and M-phases are separated by two gap phases (G1 and G2) that govern the readiness of cells to enter S- or M-phase. Genetic and biochemical studies demonstrate that cell division in eukaryotes is mediated by CDKs (cyclin-dependent kinases). Active CDKs comprise a protein kinase subunit whose catalytic activity is dependent on association with a regulatory cyclin subunit. Cell-cycle-stage-dependent accumulation and proteolytic degradation of different cyclin subunits regulates their association with CDKs to control different stages of cell division. CDKs promote cell cycle progression by phosphorylating critical downstream substrates to alter their activity. Here, we will review some of the well-characterized CDK substrates to provide mechanistic insights into how these kinases control different stages of cell division.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/74833/

Publicador

Springer Verlag

Relação

http://eprints.qut.edu.au/74833/1/SURYADINATA_2010R.pdf

DOI:10.1042/BSR20090171

Suryadinata, Randy, Sadowski, Martin, & Sarcevic, Boris (2010) Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates. Bioscience Reports, 30(4), pp. 243-255.

Direitos

Copyright 2010 The Author(s); Journal compilation copyright 2010 Biochemical Society

Fonte

Institute of Health and Biomedical Innovation

Tipo

Journal Article