Anterior temporal cortex and semantic memory : reconciling findings from neuropsychology and functional imaging
Data(s) |
2006
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Resumo |
Studies of semantic impairment arising from brain disease suggest that the anterior temporal lobes are critical for semantic abilities in humans; yet activation of these regions is rarely reported in functional imaging studies of healthy controls performing semantic tasks. Here, we combined neuropsychological and PET functional imaging data to show that when healthy subjects identify concepts at a specific level, the regions activated correspond to the site of maximal atrophy in patients with relatively pure semantic impairment. The stimuli were color photographs of common animals or vehicles, and the task was category verification at specific (e.g., robin), intermediate (e.g., bird), or general (e.g., animal) levels. Specific, relative to general, categorization activated the antero-lateral temporal cortices bilaterally, despite matching of these experimental conditions for difficulty. Critically, in patients with atrophy in precisely these areas, the most pronounced deficit was in the retrieval of specific semantic information. |
Identificador | |
Publicador |
Springer |
Relação |
DOI:10.3758/CABN.6.3.201 Rogers, Timothy T., Hocking, Julia, Noppeney, Uta, Mechelli, Andrea, Gorno-Tempini, Maria L., Patterson, Karalyn, & Price, Cathy J. (2006) Anterior temporal cortex and semantic memory : reconciling findings from neuropsychology and functional imaging. Cognitive, Affective, and Behavioral Neuroscience, 6(3), pp. 201-213. |
Direitos |
Copyright 2006 Springer |
Fonte |
Faculty of Health; School of Psychology & Counselling |
Palavras-Chave | #110903 Central Nervous System #110904 Neurology and Neuromuscular Diseases #170204 Linguistic Processes (incl. Speech Production and Comprehension) #Brain Mapping #Humans #Image Processing #Memory/*physiology #Memory Disorders/pathology/physiopathology/radionuclide imaging #*Neuropsychological Tests #*Positron-Emission Tomography #Reaction Time #*Semantics #Temporal Lobe |
Tipo |
Journal Article |