When supply does not meet demand-ER stress and plant programmed cell death
Data(s) |
04/06/2014
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Resumo |
The endoplasmic reticulum (ER) is the central organelle in the eukaryotic secretory pathway. The ER functions in protein synthesis and maturation and is crucial for proper maintenance of cellular homeostasis and adaptation to adverse environments. Acting as a cellular sentinel, the ER is exquisitely sensitive to changing environments principally via the ER quality control machinery. When perturbed, ER-stress triggers a tightly regulated and highly conserved, signal transduction pathway known as the unfolded protein response (UPR) that prevents the dangerous accumulation of unfolded/misfolded proteins. In situations where excessive UPR activity surpasses threshold levels, cells deteriorate and eventually trigger programmed cell death (PCD) as a way for the organism to cope with dysfunctional or toxic signals. The programmed cell death that results from excessive ER stress in mammalian systems contributes to several important diseases including hypoxia, neurodegeneration, and diabetes. Importantly, hallmark features and markers of cell death that are associated with ER stress in mammals are also found in plants. In particular, there is a common, conserved set of chaperones that modulate ER cell death signaling. Here we review the elements of plant cell death responses to ER stress and note that an increasing number of plant-pathogen interactions are being identified in which the host ER is targeted by plant pathogens to establish compatibility. |
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application/pdf |
Identificador | |
Publicador |
Frontiers Research Foundation |
Relação |
http://eprints.qut.edu.au/72724/1/72724.pdf DOI:10.3389/fpls.2014.00211 Williams, Brett, Verchot, Jeanmarie, & Dickman, Martin B. (2014) When supply does not meet demand-ER stress and plant programmed cell death. Frontiers in Plant Science, 5(211). |
Direitos |
Copyright © 2014 Williams, Verchot and Dickman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Fonte |
Centre for Tropical Crops and Biocommodities; Institute for Future Environments; Science & Engineering Faculty |
Palavras-Chave | #060103 Cell Development Proliferation and Death #060702 Plant Cell and Molecular Biology #Unfolded Protein Response #ER #Autophagy #Stress response and stress tolerance #PCD |
Tipo |
Journal Article |