Factors regulating basement membrane invasion by tumor cells
Contribuinte(s) |
Lippman, M.E. Dickson, R.B. |
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Data(s) |
1988
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Resumo |
Basement membranes serve as significant barriers to the passage of tumor cells but ones which metastatic cells can pass. This involves the production of a cascade of proteases leading to the activation of a specific collagenase that degrades the unique collagen network in basement membrane. Breast cancer cells, when estrogen dependent, show a requirement for estrogen for invasive activity. However, when these cells progress to an estrogen independent state and increased malignancy, they express an invasive phenotype constitutively. Studies with various anti-estrogens suggest that these responses are mediated via the estrogen receptor. Anti-estrogens lacking agonist activity suppress invasiveness as well as growth of the breast cancer cells. |
Identificador | |
Publicador |
Springer |
Relação |
http://www.springer.com/medicine/oncology/book/978-0-89838-368-3 Thompson, E.W., Reich, R., Martin, G.R., & Albini, A. (1988) Factors regulating basement membrane invasion by tumor cells. In Lippman, M.E. & Dickson, R.B. (Eds.) Breast Cancer : Cellular and Molecular Biology. Springer, Boston, MA, pp. 239-249. |
Fonte |
Faculty of Health |
Tipo |
Book Chapter |