Supplementary material : large scale read classification for next generation sequencing
Data(s) |
16/06/2014
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Resumo |
Next Generation Sequencing (NGS) has revolutionised molecular biology, resulting in an explosion of data sets and an increasing role in clinical practice. Such applications necessarily require rapid identification of the organism as a prelude to annotation and further analysis. NGS data consist of a substantial number of short sequence reads, given context through downstream assembly and annotation, a process requiring reads consistent with the assumed species or species group. Highly accurate results have been obtained for restricted sets using SVM classifiers, but such methods are difficult to parallelise and success depends on careful attention to feature selection. This work examines the problem at very large scale, using a mix of synthetic and real data with a view to determining the overall structure of the problem and the effectiveness of parallel ensembles of simpler classifiers (principally random forests) in addressing the challenges of large scale genomics. |
Formato |
application/pdf application/pdf application/pdf |
Identificador | |
Publicador |
Springer Verlag |
Relação |
http://eprints.qut.edu.au/69837/1/HoganPeutICCS2014SupplementaryMaterial.pdf http://eprints.qut.edu.au/69837/2/HoganPeutICCS2014SupplementaryMaterial.pdf http://eprints.qut.edu.au/69837/3/HoganPeutICCS2014SupplementaryMaterial.pdf Hogan, James M. & Peut, Timothy (2014) Supplementary material : large scale read classification for next generation sequencing. International Conference on Computational Science. (In Press) |
Direitos |
Copyright 2014 The Author(s) |
Fonte |
School of Electrical Engineering & Computer Science; Science & Engineering Faculty |
Palavras-Chave | #060102 Bioinformatics #080301 Bioinformatics Software #genomics #next generation sequencing #alignment free methods |
Tipo |
Other |