ortho-Bromo(propa-1,2-dien-1-yl)arenes : substrates for domino reactions


Autoria(s): Masters, Kye-Simeon; Wallesch, Manuela; Bräse, Stefan
Data(s)

29/09/2011

Resumo

o-Bromo(propa-1,2-dien-1-yl)arenes exhibit novel and orthogonal reactivity under Pd catalysis in the presence of secondary amines to form enamines (concerted Pd insertion, intramolecular carbopalladation, and terminative Buchwald–Hartwig coupling) and of amides to form indoles (addition, Buchwald–Hartwig cyclization, and loss of the acetyl group). The substrates for these reactions can be accessed in a reliable and highly selective two-step process from 2-bromoaryl bromides.

Identificador

http://eprints.qut.edu.au/69692/

Publicador

American Chemical Society

Relação

DOI:10.1021/jo201679s

Masters, Kye-Simeon, Wallesch, Manuela, & Bräse, Stefan (2011) ortho-Bromo(propa-1,2-dien-1-yl)arenes : substrates for domino reactions. The Journal of Organic Chemistry, 76(21), pp. 9060-9067.

Direitos

Copyright 2011 American Chemical Society

This article is freely available from the American Chemical Society website 12 months after the publication date. See links to publisher website in this record

Fonte

School of Chemistry, Physics & Mechanical Engineering; Science & Engineering Faculty

Palavras-Chave #030503 Organic Chemical Synthesis
Tipo

Journal Article