Enterovirus71 (EV71) utilise host microRNAs to mediate host immune system enhancing survival during infection
Data(s) |
07/07/2014
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Resumo |
Hand, Foot and Mouth Disease (HFMD) is a self-limiting viral disease that mainly affects infants and children. In contrast with other HFMD causing enteroviruses, Enterovirus71 (EV71) has commonly been associated with severe clinical manifestation leading to death. Currently, due to a lack in understanding of EV71 pathogenesis, there is no antiviral therapeutics for the treatment of HFMD patients. Therefore the need to better understand the mechanism of EV71 pathogenesis is warranted. We have previously reported a human colorectal adenocarcinoma cell line (HT29) based model to study the pathogenesis of EV71. Using this system, we showed that knockdown of DGCR8, an essential cofactor for microRNAs biogenesis resulted in a reduction of EV71 replication. We also demonstrated that there are miRNAs changes during EV71 pathogenesis and EV71 utilise host miRNAs to attenuate antiviral pathways during infection. Together, data from this study provide critical information on the role of miRNAs during EV71 infection. |
Formato |
application/pdf |
Identificador | |
Publicador |
Public Library of Science |
Relação |
http://eprints.qut.edu.au/68333/1/journal_pone_0102997.pdf DOI:10.1371/journal.pone.0102997 Lui, Yan Long Edmund, Tan, Tuan Lin, Woo, Wee Hong, Timms, Peter, Hafner, Louise M., Tan, Kian Hwa, & Tan, Eng Lee (2014) Enterovirus71 (EV71) utilise host microRNAs to mediate host immune system enhancing survival during infection. PLOS One, 9(7), e102997-1. |
Direitos |
Copyright 2014 The Author(s) This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #060506 Virology #Enterovirus 71 infectipons #Host microRNAs #Enhanced survival |
Tipo |
Journal Article |