Immune regulation during chronic visceral leishmaniasis


Autoria(s): Faleiro, Rebecca J.; Kumar, Rajiv; Hafner, Louise M.; Engwerda, Christian R.
Data(s)

10/03/2014

Resumo

Visceral leishmaniasis is a chronic parasitic disease associated with severe immune dysfunction. Treatment options are limited to relatively toxic drugs and there is no vaccine for humans available. Hence, there is an urgent need to better understand immune responses following infection with Leishmania species by studying animal models of disease and clinical samples from patients. Here, we review recent discoveries in these areas and highlight shortcomings in our knowledge that need to be addressed if better treatment options are to be developed and effective vaccines designed.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/68187/

Publicador

Public Library of Science

Relação

http://eprints.qut.edu.au/68187/2/68187.pdf

DOI:10.1371/journal.pntd.0002914

Faleiro, Rebecca J., Kumar, Rajiv, Hafner, Louise M., & Engwerda, Christian R. (2014) Immune regulation during chronic visceral leishmaniasis. PLoS Neglected Tropical Diseases, 8(7), e2914.

Direitos

Copyright 2014 The Author(s)

Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation

Palavras-Chave #060599 Microbiology not elsewhere classified #visceral leishmaniasis #immune regulation
Tipo

Journal Article