PTSD and traumatic stress : from gene to community and bench to bedside


Autoria(s): Ursano, Robert J.; Zhang, Lei; Li, He; Johnson, Luke; Carlton, Janis; Fullerton, Carol S.; Benedek, David M.
Data(s)

01/10/2009

Resumo

Individuals and communities are exposed to traumatic events, those that are accidents or naturally occurring and those that are intentional or human made. Although resilience is the expected response, for some, posttraumatic stress disorder may be the outcome. Brain models of PTSD require understanding the phenomenology of the disorder and the brain “break down” that occurs. Among several models, importantly, is the perspective that PTSD is a “forgetting” disorder. Other elements in the onset and triggers of PTSD can identify further models to examine at the bench. New studies of the 5-HT2A receptor, the glucocorticoid receptor, p11, mitochondrial genes and cannabinoids are bringing new perspectives to understanding brain function in PTSD. Effective treatments indicate areas for bench research on the mechanisms of the disorder.

Identificador

http://eprints.qut.edu.au/67971/

Publicador

Elsevier

Relação

http://www.sciencedirect.com/science/article/pii/S0006899309006040

DOI:10.1016/j.brainres.2009.03.030

Ursano, Robert J., Zhang, Lei, Li, He, Johnson, Luke, Carlton, Janis, Fullerton, Carol S., & Benedek, David M. (2009) PTSD and traumatic stress : from gene to community and bench to bedside. Brain Research, 1293, pp. 2-12.

Fonte

Faculty of Health; Institute of Health and Biomedical Innovation; School of Psychology & Counselling

Palavras-Chave #110900 NEUROSCIENCES #Stress #Posttraumatic stress disorder #PTSD #p11 #Glucocorticoid #Cannabinoid #Serotonin receptor #Model #Disaster #Trauma #Traumatic stress
Tipo

Journal Article