PTSD and traumatic stress : from gene to community and bench to bedside
Data(s) |
01/10/2009
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Resumo |
Individuals and communities are exposed to traumatic events, those that are accidents or naturally occurring and those that are intentional or human made. Although resilience is the expected response, for some, posttraumatic stress disorder may be the outcome. Brain models of PTSD require understanding the phenomenology of the disorder and the brain “break down” that occurs. Among several models, importantly, is the perspective that PTSD is a “forgetting” disorder. Other elements in the onset and triggers of PTSD can identify further models to examine at the bench. New studies of the 5-HT2A receptor, the glucocorticoid receptor, p11, mitochondrial genes and cannabinoids are bringing new perspectives to understanding brain function in PTSD. Effective treatments indicate areas for bench research on the mechanisms of the disorder. |
Identificador | |
Publicador |
Elsevier |
Relação |
http://www.sciencedirect.com/science/article/pii/S0006899309006040 DOI:10.1016/j.brainres.2009.03.030 Ursano, Robert J., Zhang, Lei, Li, He, Johnson, Luke, Carlton, Janis, Fullerton, Carol S., & Benedek, David M. (2009) PTSD and traumatic stress : from gene to community and bench to bedside. Brain Research, 1293, pp. 2-12. |
Fonte |
Faculty of Health; Institute of Health and Biomedical Innovation; School of Psychology & Counselling |
Palavras-Chave | #110900 NEUROSCIENCES #Stress #Posttraumatic stress disorder #PTSD #p11 #Glucocorticoid #Cannabinoid #Serotonin receptor #Model #Disaster #Trauma #Traumatic stress |
Tipo |
Journal Article |