Matrix metalloproteinases during wound healing - a double edged sword


Autoria(s): Rohl, Joan; Murray, Rachael
Data(s)

01/11/2013

Resumo

The extracellular matrix (ECM) provides a framework for cells and gives skin its tensile strength and elasticity. Loss of its integrity necessitates the clearing of damaged components and the deposition of firstly a provisional matrix and later remodelling of the ECM to support a functionally intact tissue. Matrix metalloproteinases (MMPs) are an important family of enzymes that function in the breakdown of the ECM and modulate the function of many biologically active molecules housed in the ECM. Through their enzymatic actions MMPs play a role in fundamental processes such as immune cell infiltration and ECM remodelling during wound repair. Their tight control is necessary for timely wound healing and excessive MMP activity participates in the development and persistence of chronic wounds, while reduced activity contributes to fibrosis. A number of inhibitors have been designed to target this activity and improve wound healing with limited success. Novel strategies are currently being investigated to improve wound healing by targeting MMP modulating molecules.

Identificador

http://eprints.qut.edu.au/67682/

Publicador

Cambridge Publishing

Relação

http://search.informit.com.au/documentSummary;dn=715191891352705;res=IELHEA

Rohl, Joan & Murray, Rachael (2013) Matrix metalloproteinases during wound healing - a double edged sword. Wound Practice and Research, 21(4), pp. 174-182.

Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation

Palavras-Chave #060000 BIOLOGICAL SCIENCES #110000 MEDICAL AND HEALTH SCIENCES #Wound Healing #Matrix metalloproteinases #Chronic wounds
Tipo

Journal Article