Role of short RNAs in gene silencing
Data(s) |
2001
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Resumo |
Recent research has revealed the existence of an elegant defence mechanism in plants and lower eukaryotes. The mechanism, known in plants as post-transcriptional gene silencing, works through sequence-specific degradation of RNA. It appears to be directed by double-stranded RNA, associated with the production of short 21-25 nt RNAs, and spread through the plant by a diffusible signal. The short RNAs are implicated as the guides for both a nuclease complex that degrades the mRNA and a methyltransferase complex that methylates the DNA of silenced genes. It has also been suggested that these short RNAs might be the mobile silencing signal, a suggestion that has been challenged recently. |
Identificador | |
Publicador |
Elsevier Ltd. * Trends Journals |
Relação |
DOI:10.1016/S1360-1385(01)01989-6 Waterhouse, Peter M., Wang, Ming-Bo, & Finnegan, E. Jean (2001) Role of short RNAs in gene silencing. Trends in Plant Science, 6(7), pp. 297-301. |
Direitos |
Copyright 2001 Elsevier Ltd. |
Fonte |
School of Earth, Environmental & Biological Sciences; Science & Engineering Faculty |
Palavras-Chave | #060400 GENETICS #060700 PLANT BIOLOGY #cysteine proteinase #double stranded RNA #HC Pro protein #potyvirus #HC-Pro protein #potyvirus #methyltransferase #plant DNA #plant RNA #vegetable protein #virus protein #adaptation #comparative study #DNA methylation #gene #gene silencing #genetic transcription #genetics #metabolism #physiology #plant #plant virus #review #RNA processing #signal transduction #transgenic plant #Adaptation #Physiological #Cysteine Endopeptidases #DNA #Plant #Genes #Plant #Methyltransferases #Plant Proteins #Plant Viruses #Plants #Plants #Genetically Modified #RNA Processing #Post-Transcriptional #RNA #Double-Stranded #RNA #Plant #Transcription #Genetic #Viral Proteins |
Tipo |
Journal Article |