Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine
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01/01/2014
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Resumo |
Introduction: Domperidone is a dopamine D2-receptor antagonist developed as an antiemetic and prokinetic agents. Oral domperidone is not approved in the US, but is used in many countries to treat nausea and vomiting, gastroparesis, and as a galactogogue (to promote lactation). The US Food and Drug Administration (FDA) have issued a warning about the cardiac safety of domperidone. Areas covered: The authors undertook a review of the cardiac safety of oral domperidone. Expert opinion: The data from preclinical studies are unambiguous in identifying domperidone as able to produce marked hERG channel inhibition and action potential prolongation at clinically relevant concentrations. The compound’s propensity to augment instability of action potential duration and action potential triangulation are also indicative of proarrhythmic potential. Domperidone should not be administered to subjects with pre-existing QT prolongation/LQTS, subjects receiving drugs that inhibit CYP3A4, subjects with electrolyte abnormalities or with other risk factors for QT-prolongation. With these provisos, it is possible that domperidone may be used as a galactogogue without direct risk to healthy breast feeding women but more safety information should be sought in this situation. Also, more safety information is required regarding risk to breast feeding infants or before domperidone is routinely used in gastroparesis or gastroesphageal reflux in children. |
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application/pdf |
Identificador | |
Publicador |
Informa Healthcare |
Relação |
http://eprints.qut.edu.au/65613/2/65613.pdf DOI:10.1517/14740338.2014.851193 Doggrell, Sheila A & Hancox, Jules C (2014) Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine. Expert Opinion on Drug Safety, 13(1), pp. 131-138. |
Direitos |
Copyright 2013 Informa Healthcare |
Fonte |
School of Biomedical Sciences; Faculty of Health |
Palavras-Chave | #111500 PHARMACOLOGY AND PHARMACEUTICAL SCIENCES #domperidone, #cardiac safety #proarrhythmia, QT interval, torsades de pointes #anti-emetic #galactogogue |
Tipo |
Journal Article |