Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine


Autoria(s): Doggrell, Sheila A; Hancox, Jules C
Data(s)

01/01/2014

Resumo

Introduction: Domperidone is a dopamine D2-receptor antagonist developed as an antiemetic and prokinetic agents. Oral domperidone is not approved in the US, but is used in many countries to treat nausea and vomiting, gastroparesis, and as a galactogogue (to promote lactation). The US Food and Drug Administration (FDA) have issued a warning about the cardiac safety of domperidone. Areas covered: The authors undertook a review of the cardiac safety of oral domperidone. Expert opinion: The data from preclinical studies are unambiguous in identifying domperidone as able to produce marked hERG channel inhibition and action potential prolongation at clinically relevant concentrations. The compound’s propensity to augment instability of action potential duration and action potential triangulation are also indicative of proarrhythmic potential. Domperidone should not be administered to subjects with pre-existing QT prolongation/LQTS, subjects receiving drugs that inhibit CYP3A4, subjects with electrolyte abnormalities or with other risk factors for QT-prolongation. With these provisos, it is possible that domperidone may be used as a galactogogue without direct risk to healthy breast feeding women but more safety information should be sought in this situation. Also, more safety information is required regarding risk to breast feeding infants or before domperidone is routinely used in gastroparesis or gastroesphageal reflux in children.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/65613/

Publicador

Informa Healthcare

Relação

http://eprints.qut.edu.au/65613/2/65613.pdf

DOI:10.1517/14740338.2014.851193

Doggrell, Sheila A & Hancox, Jules C (2014) Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine. Expert Opinion on Drug Safety, 13(1), pp. 131-138.

Direitos

Copyright 2013 Informa Healthcare

Fonte

School of Biomedical Sciences; Faculty of Health

Palavras-Chave #111500 PHARMACOLOGY AND PHARMACEUTICAL SCIENCES #domperidone, #cardiac safety #proarrhythmia, QT interval, torsades de pointes #anti-emetic #galactogogue
Tipo

Journal Article