A role for IGF-1R-targeted therapies in small-cell lung cancer?
Data(s) |
2011
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Resumo |
Background: Small-cell lung cancer (SCLC) is an aggressive disease with a poor prognosis. The insulin-like growth factor-1 receptor (IGF-1R) is an autocrine growth factor and an attractive therapeutic target in many solid tumors, but particularly in lung cancer. Patients and Methods: This study examined tumor samples from 23 patients diagnosed with SCLC, 11 resected specimens and 12 nodal biopsies obtained by mediastinoscopy, for expression of IGF-1R using the monoclonal rabbit anti-IGF-1R (clone G11, Ventana Medical Systems, Tucson, AZ) and standard immunohistochemistry (IHC). Results: All 23 tumor samples expressed IGF-1R with a range of stain intensity from weak (1+) to strong (3+). Ten tumors had a score of 3+, 7 tumors 2+, and 6 tumors 1+. Patient survival data were available for all 23 patients. Two patients died < 30 days post biopsy, therefore, the intensity of anti-IGF-1R immunostaining for 21 patients was correlated to survival. Patients with 3+ immunostaining had a poorer prognosis (P = .003). The overall survival of patients who underwent surgical resection was significantly better (median survival not reached) than patients who were not resected (median survival, 7.4 months) (P = .006). Conclusion: IGF-1R targeted therapies may have a role in the treatment of SCLC in combination with chemotherapy or as maintenance therapy. Further studies on the clinical benefit of targeting IGF-1R in SCLC are needed. |
Identificador | |
Publicador |
Elsevier Inc. |
Relação |
DOI:10.3816/CLC.2011.n.005 Gately, K., Collins, I., Forde, L., Al-Alao, B., Young, V., Gerg, M., Feuerhake, F., & O'Byrne, Kenneth J. (2011) A role for IGF-1R-targeted therapies in small-cell lung cancer? Clinical Lung Cancer, 12(1), pp. 38-42. |
Direitos |
Copyright 2011 Elsevier. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #Biomarker #Immunohistochemistry #somatomedin C receptor #adult #aged #article #cancer chemotherapy #cancer surgery #cancer survival #clinical article #controlled study #female #histopathology #human #human cell #human tissue #lobectomy #lung biopsy #lung resection #lung small cell cancer #maintenance therapy #male #mediastinoscopy #overall survival #prognosis #protein expression #survival rate #survival time #Western blotting #Blotting #Western #Humans #Kaplan-Meier Estimate #Lung Neoplasms #Middle Aged #Receptor #IGF Type 1 #Small Cell Lung Carcinoma #Tumor Markers #Biological |
Tipo |
Journal Article |