Coffee and chemoprevention – the genotype decides
Resumo |
In a human intervention study comprising 49 healthy participants, coffee combining natural green coffee bean constituents and dark roast products was identified as a genotype-dependent inducer of Nrf2, significantly affecting Nrf2 gene expression and downstream transcription. Specifically, with 65% of participants showing ≥1.5 fold increase in Nrf2-transcription, the presence of the -651G/A SNP in the Nrf2 gene in conjunction with heterozygosity of the 6/7 AT repeat sequence in the UGT1A1 gene significantly down-regulated coffee-mediated gene expression. Considering the role of the Nrf/ARE pathway in the regulation of antioxidative and chemopreventive phase II efficacy, individual genotype must be considered when examining the potency of bioactive food/food constituents and therapeutic potential. |
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Formato |
application/pdf |
Identificador | |
Relação |
http://eprints.qut.edu.au/63742/1/63742.pdf Boettler, Ute, Haupt, Larisa M., Smith, Robert A., Bytof, Gerhard, Lantz, Ingo, Griffiths, Lyn R., & Marko, Doris Coffee and chemoprevention – the genotype decides. [Working Paper] (Unpublished) |
Direitos |
Copyright the authors |
Fonte |
Institute of Health and Biomedical Innovation |
Palavras-Chave | #Reactive oxygen species #antioxidant #coffee #Nrf2 genotype #genetic variations #gene expression |
Tipo |
Working Paper |