Genetic susceptibility to complex traits : moving towards informed analysis of whole-genome screens


Autoria(s): Green, Michael R.; Camilleri, Emily; Gandhi, Maher K.; Griffiths, Lyn R.
Contribuinte(s)

Matsumoto, Akio

Nakano, Mai

Data(s)

2009

Resumo

Susceptibility to complex traits, by definition, involves aetiological polymorphisms at multiple genetic loci combined with variable contributions by environmental factors. However, the approaches taken to identifying genetic loci implicated in susceptibility to complex traits frequently overlooks the compounding contribution of multiple loci in favour of highlighting a single gene solely responsible for predisposition. It is only in a small minority of cases that this has resulted in clear disease heritability associated with polymorphisms in a single gene. More often, this approach has led to an accumulation of single-gene associations with minor contributions to disease susceptibility. As the genomic era advances and genome-wide screens become higher in resolution and throughput, the need for simultaneous consideration of multiple loci is becoming more important. With special reference to non-Hodgkin’s lymphoma (NHL), this chapter will overview the current progress made in elucidating genetic polymorphisms associated with disease susceptibility. We also present novel data from a high-resolution single nucleotide polymorphism (SNP) microarray screen for susceptibility loci that are involved in NHL. Using an ‘informed approach’, the findings are highlighted within the context of cellular pathways, and provide insight and new ideas for methods of analysis for genome-wide screens for susceptibility.

Identificador

http://eprints.qut.edu.au/63661/

Publicador

Nova Science Publishers

Relação

https://www.novapublishers.com/catalog/product_info.php?products_id=10162

Green, Michael R., Camilleri, Emily, Gandhi, Maher K., & Griffiths, Lyn R. (2009) Genetic susceptibility to complex traits : moving towards informed analysis of whole-genome screens. In Matsumoto, Akio & Nakano, Mai (Eds.) The Human Genome : Features, Variations and Genetic Disorders. Nova Science Publishers, New York USA, pp. 167-180.

Direitos

Copyright 2009 Nova Science Publishers

Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation

Tipo

Book Chapter