Association of a low density lipoprotein receptor microsatellite variant with obesity
Data(s) |
1997
|
---|---|
Resumo |
OBJECTIVE To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. DESIGN A cross-sectional case-control study. SUBJECTS One hundred and seven obese individuals, defined as a body mass index (BMI) ≤ 26 kg/m2, and 163 lean individuals, defined as a BMI < 26 kg/m2. MEASUREMENTS BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). RESULTS There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ2 = 12.3, P = 0.002), but not in males (χ2 = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. CONCLUSIONS These results suggest that in females, LDLR may play a role in the development of obesity. |
Identificador | |
Publicador |
Nature Publishing Group |
Relação |
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030809211&partnerID=40&md5=645d5ca1ba30cac565918810dd5d073a Rutherford, S., Nyholt, D.R., Curtain, R.P., Quinlan, S.R., Gaffney, P.T., Morris, B.J., & Griffiths, L.R. (1997) Association of a low density lipoprotein receptor microsatellite variant with obesity. International Journal of Obesity, 21(11), pp. 1032-1037. |
Direitos |
Copyright 1997 Nature Publishing Group |
Fonte |
Institute of Health and Biomedical Innovation |
Palavras-Chave | #Association study #BMI #Microsatellite polymorphism #Molecular genetics #Obesity #PCR #lipid #low density lipoprotein receptor #microsatellite dna #allele #article #blood pressure measurement #body mass #controlled study #dna polymorphism #female #human #human experiment #lipid blood level #male #obesity #polymerase chain reaction #priority journal #Alleles #Analysis of Variance #Body Mass Index #Case-Control Studies #Cross-Sectional Studies #Female #Genotype #Humans #Hypertension #Lipids #Male #Microsatellite Repeats #Obesity #Polymorphism #Genetic #Receptors #LDL |
Tipo |
Journal Article |