Composites for delivery of therapeutics : combining melt electrospun scaffolds with loaded electrosprayed microparticles


Autoria(s): Bock, Nathalie; Woodruff, Maria A.; Steck, Roland; Hutmacher, Dietmar; Farrugia, Brooke L.; Dargaville, Tim R.
Data(s)

2014

Resumo

A novel strategy is reported to produce biodegradable microfiber-scaffolds layered with high densities of microparticles encapsulating a model protein. Direct electrospraying on highly porous melt electrospun scaffolds provides a reproducible scaffold coating throughout the entire architecture. The burst release of protein is significantly reduced due to the immobilization of microparticles on the surface of the scaffold and release mechanisms are dependent on protein-polymer interactions. The composite scaffolds have a positive biological effect in contact with precursor osteoblast cells up to 18 days in culture. The scaffold design achieved with the techniques presented here endorses these new composite scaffolds as promising templates for growth factor delivery.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/62833/

Publicador

John Wiley & Sons

Relação

http://eprints.qut.edu.au/62833/1/2013004625.pdf

DOI:10.1002/mabi.201300276

Bock, Nathalie, Woodruff, Maria A., Steck, Roland, Hutmacher, Dietmar, Farrugia, Brooke L., & Dargaville, Tim R. (2014) Composites for delivery of therapeutics : combining melt electrospun scaffolds with loaded electrosprayed microparticles. Macromolecular Bioscience, 14(2), pp. 202-214.

http://purl.org/au-research/grants/ARC/LP100200084-LP110200082

Direitos

Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

The definitive version is available at www3.interscience.wiley.com

Fonte

Faculty of Health; Institute of Health and Biomedical Innovation; Science & Engineering Faculty

Palavras-Chave #090301 Biomaterials #090304 Medical Devices #091202 Composite and Hybrid Materials #111504 Pharmaceutical Sciences #Drug Delivery #Electrospraying #Microstuructures #Polymer-Drug Interactions #Tissue Engineering
Tipo

Journal Article