The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma.


Autoria(s): Hacker, Elke; Boyce, Zachary; Kimlin, Michael G.; Wockner, Leesa; Pollak, Thomas; Vaartjes, Arthur Samuel; Hayward, Nicholas K.; Whiteman, David C.
Data(s)

21/08/2013

Resumo

We conducted a clinical trial to compare the molecular and cellular responses of human melanocytes and keratinocytes in vivo to solar-simulated ultraviolet radiation (SSUVR) in 57 Caucasian participants grouped according to MC1R genotype. We found that, on average, the density of epidermal melanocytes 14 days after exposure to 2 minimal erythemal dose (MED) SSUVR was twofold higher than baseline (unirradiated) skin. However, the change in epidermal melanocyte counts among people carrying germline MC1R variants (97% increase) was significantly less than those with wild-type MC1R (164% increase; P = 0.01). We also found that sunscreen applied to the skin before exposure to 2 MED SSUVR completely blocked the effects of DNA damage, p53 induction, and cellular proliferation in both melanocytes and keratinocytes.

Identificador

http://eprints.qut.edu.au/62413/

Publicador

Wiley-Blackwell Publishing, Inc.

Relação

DOI:10.1111/pcmr.12157

Hacker, Elke, Boyce, Zachary, Kimlin, Michael G., Wockner, Leesa, Pollak, Thomas, Vaartjes, Arthur Samuel, Hayward, Nicholas K., & Whiteman, David C. (2013) The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma. Pigment Cell & Melanoma Research.

Fonte

Faculty of Health; Institute of Health and Biomedical Innovation; School of Public Health & Social Work

Palavras-Chave #110000 MEDICAL AND HEALTH SCIENCES #111700 PUBLIC HEALTH AND HEALTH SERVICES #MC1R #Melanocytes #Melanoma #Proliferation #Sun Exposure
Tipo

Journal Article