Poly(2-oxazoline) hydrogels for controlled fibroblast attachment
Data(s) |
2013
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Resumo |
Currently there is a lack of choice when selecting synthetic materials with the cell-instructive properties demanded by modern biomaterials. The purpose of this study was to investigate the attachment of cells onto hydrogels prepared from poly(2-oxazoline)s selectively-functionalized with cell adhesion motifs. A water-soluble macromer based on the microwave-assisted cationic ring-opening polymerization of 2-methyl-2-oxazoline and 2-(dec-9-enyl)-2-oxazoline was functionalized with the peptide CRGDSG or controls using thiol-ene photochemistry followed by facile crosslinking in the presence of a dithiol crosslinker. The growth of human fibroblasts on the hydrogel surfaces was dictated by the structure and amount of incorporated peptide. Controls without any peptide showed resistance to cellular attachment. The benignity of the crosslinking conditions was demonstrated by the incorporation of fibroblasts within the hydrogels to produce three-dimensional cell-polymer constructs. |
Formato |
application/pdf |
Identificador | |
Publicador |
American Chemical Society |
Relação |
http://eprints.qut.edu.au/61888/2/PMeOx_RGD_manuscript_16.pdf DOI:10.1021/bm400518h Farrugia, Brooke L., Kempe, Kristian, Schubert, Ulrich S., Hoogenboom, Richard, & Dargaville, Tim R. (2013) Poly(2-oxazoline) hydrogels for controlled fibroblast attachment. Biomacromolecules, 14(8), pp. 2724-2732. |
Direitos |
Copyright 2013 American Chemical Society |
Fonte |
Institute of Health and Biomedical Innovation; Science & Engineering Faculty |
Palavras-Chave | #030300 MACROMOLECULAR AND MATERIALS CHEMISTRY #030306 Synthesis of Materials #poly(2-oxazoline) #hydrogel #fibroblast #cell adhesion #thiol-ene #photocure |
Tipo |
Journal Article |