A study of the diffusion characteristics of normal, delipidized and relipidized articular cartilage using magnetic resonance imaging


Autoria(s): Yusuf, Kenny; Momot, Konstantin I.; Wellard, R. Mark; Oloyede, Adekunle
Data(s)

2013

Resumo

This paper assesses the capacity to provide semipermeability of the synthetic layer of surface-active phospholipids created to replace the depleted surface amorphous layer of articular cartilage. The surfaces of articular cartilage specimens in normal, delipidized, and relipidized conditions following incubation in dipalmitoyl-phosphatidylcholine and palmitoyl-oleoyl-phosphatidylcholine components of the joint lipid mixture were characterized nanoscopically with the atomic force microscope and also imaged as deuterium oxide (D2O) diffused transiently through these surfaces in a magnetic resonance imaging enclosure. The MR images were then used to determine the apparent diffusion coefficients in a purpose-built MATLAB®-based algorithm. Our results revealed that all surfaces were permeable to D2O, but that there was a significant difference in the semipermeability of the surfaces under the different conditions, relative to the apparent diffusion coefficients. Based on the results and observations, it can be concluded that the synthetic lipid that is deposited to replace the depleted SAL of articular cartilage is capable of inducing some level of semipermeability.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/61527/

Publicador

Springer

Relação

http://eprints.qut.edu.au/61527/1/Yusuf-et-al-Manuscript-edited.pdf

DOI:10.1007/s10856-013-4858-9

Yusuf, Kenny, Momot, Konstantin I., Wellard, R. Mark, & Oloyede, Adekunle (2013) A study of the diffusion characteristics of normal, delipidized and relipidized articular cartilage using magnetic resonance imaging. Journal of Materials Science : Materials in Medicine, 24(4), pp. 1005-1013.

Direitos

Copyright 2013 Springer Science+Business Media

The final publication is available at link.springer.com

Fonte

Institute of Health and Biomedical Innovation; Science & Engineering Faculty

Palavras-Chave #029903 Medical Physics #090301 Biomaterials #Articular cartilage surface #Semipermeability #Apparent diffusion coefficient #Surface amorphous layer #Surface-active phospholipids #Magnetic resonance imaging
Tipo

Journal Article