Mapping quantitative trait loci in a wild population using linkage and linkage disequilibrium analyses


Autoria(s): Hernandez Sanchez, J.; Chatzpili, A.; Beraldi, D.; Gratten , J.; Pilkington, J. G.; Pemberton, J. M.
Data(s)

01/08/2010

Resumo

Historical information can be used, in addition to pedigree, traits and genotypes, to map quantitative trait locus (QTL) in general populations via maximum likelihood estimation of variance components. This analysis is known as linkage disequilibrium (LD) and linkage mapping, because it exploits both linkage in families and LD at the population level. The search for QTL in the wild population of Soay sheep on St. Kilda is a proof of principle. We analysed the data from a previous study and confirmed some of the QTLs reported. The most striking result was the confirmation of a QTL affecting birth weight that had been reported using association tests but not when using linkage-based analyses. Copyright © Cambridge University Press 2010.

Identificador

http://eprints.qut.edu.au/58633/

Publicador

Cambridge University Press

Relação

DOI:10.1017/S0016672310000340

Hernandez Sanchez, J., Chatzpili, A., Beraldi, D., Gratten , J., Pilkington, J. G., & Pemberton, J. M. (2010) Mapping quantitative trait loci in a wild population using linkage and linkage disequilibrium analyses. Genetics Research, 92(4), pp. 273-281.

Direitos

Copyright 2010 Cambridge University Press

Fonte

Institute of Health and Biomedical Innovation

Palavras-Chave #070201 Animal Breeding #article; birth weight; body weight; gene linkage disequilibrium; gene mapping; genetic association; nonhuman; quantitative trait locus; sheep #Alleles; Animals; Chromosome Mapping; Genetic Markers; Linkage Disequilibrium; Microsatellite Repeats; Models, Statistical; Phenotype; Quantitative Trait Loci; Sheep #Ovis aries
Tipo

Journal Article