Paradoxical roles of tumour necrosis factor-alpha in prostate cancer biology


Autoria(s): Tse, Brian W.C.; Scott, Kieran F.; Russell, Pamela J.
Data(s)

2012

Resumo

Tumour necrosis factor (TNF) is a pleiotropic cytokine with dual roles in cancer biology including prostate cancer (PCa). On the one hand, there is evidence that it stimulates tumour angiogenesis, is involved in the initiation of PCa from an androgen-dependent to a castrate resistant state, plays a role in epithelial to mesenchymal plasiticity, and may contribute to the aberrant regulation of eicosanoid pathways. On the other hand, TNF has also been reported to inhibit neovascularisation, induce apoptosis of PCa cells, and stimulate anti-tumour immunity. Much of the confusion surrounding its seemingly paradoxical roles in cancer biology stems from the dependence of its effects on the biological model within which TNF is investigated. This review will address some of these issues, and also discuss on the therapeutic implications.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/55262/

Publicador

Hindawi Publishing Corporation

Relação

http://eprints.qut.edu.au/55262/8/55262%28pub%29.pdf

DOI:10.1155/2012/128965

Tse, Brian W.C., Scott, Kieran F., & Russell, Pamela J. (2012) Paradoxical roles of tumour necrosis factor-alpha in prostate cancer biology. Prostate Cancer, 2012, pp. 1-8.

Direitos

Copyright 2012 Hindawi Publishing Corporation

Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation

Palavras-Chave #111201 Cancer Cell Biology #tumour necrosis #tumour necrosis factor-alpha #prostate cancer #TNF signalling #Cytokine #Angiogenesis #epithelial to mesenchymal plasticity
Tipo

Journal Article