Immunogenicity of an HPV-16 L2 DNA vaccine


Autoria(s): Hitzeroth, I. I.; Passmore, J. A. S.; Shephard, E.; Stewart, D.; Müller, M.; Williamson, A. L.; Rybicki, E. P.; Kast, W. M.
Data(s)

2009

Resumo

The ability to elicit cross-neutralizing antibodies makes human papillomavirus (HPV) L2 capsid protein a possible HPV vaccine. We examined and compared the humoral response of mice immunized with a HPV-16 L2 DNA vaccine or with HPV-16 L2 protein. The L2 DNA vaccine elicited a non-neutralizing antibody response unlike the L2 protein. L2 DNA vaccination suppressed the growth of L2-expressing C3 tumor cells, which is a T cell mediated effect, demonstrating that the lack of non-neutralizing antibody induction by L2 DNA was not caused by lack of T cell immunogenicity of the construct. © 2009 Elsevier Ltd. All rights reserved.

Identificador

http://eprints.qut.edu.au/54983/

Relação

DOI:10.1016/j.vaccine.2009.06.015

Hitzeroth, I. I., Passmore, J. A. S., Shephard, E., Stewart, D., Müller, M., Williamson, A. L., Rybicki, E. P., & Kast, W. M. (2009) Immunogenicity of an HPV-16 L2 DNA vaccine. Vaccine, 27(46), pp. 6432-6434.

Palavras-Chave #1.2 protein #DNA vaccine #Human papillomavirus #Immunogenicity
Tipo

Journal Article