The interactions between insulin and androgens in progression to castrate resistant prostate cancer
Data(s) |
03/04/2012
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Resumo |
An association between the metabolic syndrome and reduced testosterone levels has been identified, and a specific inverse relationship between insulin and testosterone levels suggests that an important metabolic crosstalk exists between these two hormonal axes; however, the mechanisms by which insulin and androgens may be reciprocally regulated are not well described. Androgen-dependant gene pathways regulate the growth and maintenance of both normal and malignant prostate tissue, and androgen-deprivation therapy (ADT) in patients exploits this dependence when used to treat recurrent and metastatic prostate cancer resulting in tumour regression. A major systemic side effect of ADT includes induction of key features of the metabolic syndrome and the consistent feature of hyperinsulinaemia. Recent studies have specifically identified a correlation between elevated insulin and high-grade PCa and more rapid progression to castrate resistant disease. This paper examines the relationship between insulin and androgens in the context of prostate cancer progression. Prostate cancer patients present a promising cohort for the exploration of insulin stabilising agents as adjunct treatments for hormone deprivation or enhancers of chemosensitivity for treatment of advanced prostate cancer. |
Formato |
application/pdf |
Identificador | |
Publicador |
Hindawi Publishing Corporation |
Relação |
http://eprints.qut.edu.au/54725/1/1_The_interactions_between_Insulin_and_Androgens.pdf DOI:10.1155/2012/248607 Gunter, Jennifer H., Lubik, Amy A., McKenzie, Ian, Pollak, Michael, & Nelson, Colleen C. (2012) The interactions between insulin and androgens in progression to castrate resistant prostate cancer. Advances in Urology, 2012, pp. 1-11. |
Direitos |
Copyright 2012 Jennifer H. Gunter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #110102 Medical Biochemistry - Carbohydrates #111201 Cancer Cell Biology #111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy) #prostate cancer #insulin #diabetes #metabolic syndrome #cancer cell biology #cancer therapy #castration resistant prostate cancer #androgen deprivation therapy #cancer progression |
Tipo |
Journal Article |