The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease


Autoria(s): Seim, Inge; Walpole, Carina; Amorim, Laura; Josh, Peter; Herington, Adrian; Chopin, Lisa
Data(s)

01/04/2011

Resumo

Obestatin is a 23 amino acid, ghrelin gene-derived peptide hormone produced in the stomach and a range of other tissues throughout the body. While it was initially reported that obestatin opposed the actions of ghrelin with regards to appetite and food intake, it is now clear that obestatin is not an endogenous ghrelin antagonist of ghrelin, but it is a multi-functional peptide hormone in its own right. In this review we will discuss the controversies associated with the discovery of obestatin and explore emerging central and peripheral roles of obestatin, roles in adipogenesis, pancreatic homeostasis and cancer.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/41849/

Publicador

Elsevier Ireland Ltd

Relação

http://eprints.qut.edu.au/41849/2/41849.pdf

DOI:10.1016/j.mce.2011.03.018

Seim, Inge, Walpole, Carina, Amorim, Laura, Josh, Peter, Herington, Adrian, & Chopin, Lisa (2011) The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease. Molecular and Cellular Endocrinology.

Direitos

Copyright 2011 Elsevier

Fonte

Faculty of Science and Technology; Institute of Health and Biomedical Innovation

Palavras-Chave #060100 BIOCHEMISTRY AND CELL BIOLOGY #ghrelin gene #ghrelin preprohormone #obestatin
Tipo

Journal Article