Foreword
Data(s) |
01/05/2011
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Resumo |
Ghrelin was first identified in 1999 by Kojima and colleagues (Kojima et al. 1999) as the natural ligand of an orphan G-protein coupled receptor, the Growth Hormone (GH) secretagogue receptor (GHS-R), which had been identified several years earlier through the actions of a growing number of synthetic growth hormone releasing peptides (GHRPs) and non-peptidyl GH secretagogues (Howard et al. 1996). Early studies, therefore, focussed on the actions of ghrelin as an important regulator of GH secretion. As a result Kojima et al (1999) designated this GH-releasing peptide, ghrelin (ghre is the Proto-Indo-European root of the word 'grow'). We now recognise that the functions of ghrelin extend well beyond its GH releasing actions and that it is a multi-functional peptide with both endocrine and autocrine/paracrine modes of action. |
Formato |
application/pdf |
Identificador | |
Publicador |
Elsevier Ireland Ltd |
Relação |
http://eprints.qut.edu.au/41846/2/41846.pdf DOI:10.1016/j.mce.2011.05.001 Herington, Adrian C. & Chopin, Lisa K. (2011) Foreword. Molecular and Cellular Endocrinology. |
Direitos |
Copyright 2011 Elsevier |
Fonte |
Faculty of Science and Technology; Institute of Health and Biomedical Innovation |
Palavras-Chave | #060100 BIOCHEMISTRY AND CELL BIOLOGY #ghrelin #ghrelin receptor #obestatin |
Tipo |
Journal Article |