Chlamydia pneumoniae is genetically diverse in animals and appears to have crossed the host barrier to humans on (at least) two occasions


Autoria(s): Dykhuizen, Dan; Mitchell, Candice M.; Hutton, Susan; Myers, Garry S. A.; Brunham, Robert; Timms, Peter
Data(s)

10/05/2010

Resumo

Chlamydia pneumoniae is a common human and animal pathogen associated with a wide range of diseases. Since the first isolation of C. pneumoniae TWAR in 1965, all human isolates have been essentially clonal, providing little evolutionary insight. To address this gap, we investigated the genetic diversity of 30 isolates from diverse geographical locations, from both human and animal origin (amphibian, reptilian, equine and marsupial). Based on the level of variation that we observed at 23 discreet gene loci, it was clearly evident that the animal isolates were more diverse than the isolates of human origin. Furthermore, we show that C. pneumoniae isolates could be grouped into five major genotypes, A-E, with A, B, D and E genotypes linked by geographical location, whereas genotype C was found across multiple continents. Our evidence strongly supports two separate animal-to-human cross species transfer events in the evolutionary history of this pathogen. The C. pneumoniae human genotype identified in the USA, Canada, Taiwan, Iran, Japan, Korea and Australia (non- Indigenous) most likely originated from a single amphibian or reptilian lineage, which appears to have been previously geographically widespread. We identified a separate human lineage present in two Australian Indigenous isolates (independent geographical locations). This lineage is distinct and is present in Australian amphibians as well as a range of Australian marsupials.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/40649/

Publicador

Public Library of Science

Relação

http://eprints.qut.edu.au/40649/1/40649.pdf

DOI:10.1371/journal.ppat.1000903

Dykhuizen, Dan, Mitchell, Candice M., Hutton, Susan, Myers, Garry S. A., Brunham, Robert, & Timms, Peter (2010) Chlamydia pneumoniae is genetically diverse in animals and appears to have crossed the host barrier to humans on (at least) two occasions. PLoS Pathogens, 6(5), e1000903.

Direitos

Copyright 2010 Mitchell et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Fonte

Cell & Molecular Biosciences; Faculty of Science and Technology

Palavras-Chave #110309 Infectious Diseases #110800 MEDICAL MICROBIOLOGY #Chlamydia pneumoniae #pathogens
Tipo

Journal Article