Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins


Autoria(s): Seck, Tetsu M.; Melchels, Ferry P.W.; Feijen, Jan; Grijpma, Dirk W.
Data(s)

20/11/2010

Resumo

Designed three-dimensional biodegradable poly(ethylene glycol)/poly(D,L-lactide) hydrogel structures were prepared for the first time by stereolithography at high resolutions. A photopolymerisable aqueous resin comprising PDLLA-PEG-PDLLA-based macromer, visible light photo-initiator, dye and inhibitor in DMSO/water was used to build the structures. Porous and non-porous hydrogels with well-defined architectures and good mechanical properties were prepared. Porous hydrogel structures with a gyroid pore network architecture showed narrow pore size distributions, excellent pore interconnectivity and good mechanical properties. The structures showed good cell seeding characteristics, and human mesenchymal stem cells adhered and proliferated well on these materials.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/38862/

Publicador

Elsevier

Relação

http://eprints.qut.edu.au/38862/1/c38862.pdf

DOI:10.1016/j.jconrel.2010.07.111

Seck, Tetsu M., Melchels, Ferry P.W., Feijen, Jan, & Grijpma, Dirk W. (2010) Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins. Journal of Controlled Release, 148(1), pp. 34-41.

Direitos

Copyright 2010 Elsevier B.V. All rights reserved.

Fonte

Faculty of Built Environment and Engineering; Institute of Health and Biomedical Innovation; School of Engineering Systems

Palavras-Chave #090301 Biomaterials #Biodegradable hydrogels #designed porous structures #stereolithography #macromer photopolymerisation #tissue engineering
Tipo

Journal Article