Cell interactions of osteoarthritic subchondral bone osteoblasts and articular chondrocytes aggravate MMP-2 and MMP-9 production through the mediation of ERK1/2 and JNK phosphorylation
| Data(s) |
2010
|
|---|---|
| Resumo |
Matrix Metalloproteinases (MMP) play a key role in osteoarthritis (OA) development. The aim of the present study was to investigate whether, the cross-talk between subchondral bone osteoblasts (SBOs) and articular cartilage chondrocytes (ACCs) in OA alters the expression and regulation of MMPs, and also to test the potential involvement of mitogen activated protein kinase (MAPK) signalling pathway during this process. |
| Formato |
application/pdf |
| Identificador | |
| Publicador |
AO Research Institute Davos |
| Relação |
http://eprints.qut.edu.au/38164/1/c38164.pdf http://www.ecmjournal.org/journal/supplements/vol020supp02/vol020supp02.htm Prasadam, Indira, Crawford, Ross W., & Xiao, Yin (2010) Cell interactions of osteoarthritic subchondral bone osteoblasts and articular chondrocytes aggravate MMP-2 and MMP-9 production through the mediation of ERK1/2 and JNK phosphorylation. In European Cells and Materials, AO Research Institute Davos , Davos Congress Centre, Davos, Switzerland, p. 7. |
| Direitos |
Copyright 2010 [please consult the authors] |
| Fonte |
Faculty of Built Environment and Engineering; Institute of Health and Biomedical Innovation; School of Engineering Systems |
| Palavras-Chave | #060100 BIOCHEMISTRY AND CELL BIOLOGY #cell interaction #Osteoathritis #MMP-2 #MMP-9 #ERK 1/2 #Osteoblast #Articular chondrocyte |
| Tipo |
Conference Paper |
