Patterns, correlates, and prognostic significance of quality of life following breast cancer
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01/06/2011
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Resumo |
Objective To describe quality of life (QOL) over a 12-month period among women with breast cancer, consider the association between QOL and overall survival (OS), and explore characteristics associated with QOL declines. Methods A population-based sample of Australian women (n=287) with invasive, unilateral breast cancer (Stage I+), was observed prospectively for a median of 6.6 years. QOL was assessed at six, 12 and 18 months post-diagnosis, using the Functional Assessment of Cancer Therapy, Breast (FACT-B+4) questionnaire. Raw scores for the FACT-B+4 and subscales were computed and individuals were categorized according to whether QOL declined, remained stable or improved between six and 18 months. Kaplan-Meier and Cox proportional hazards survival methods were used to estimate OS and its associations with QOL. Logistic regression models identified factors associated with QOL decline. Results Within FACT-B+4 sub-scales, between 10% and 23% of women showed declines in QOL. Following adjustment for established prognostic factors, emotional wellbeing and FACT-B+4 scores at six months post-diagnosis were associated with OS (p<0.05). Declines in physical (p<0.01) or functional (p=0.02) well-being between six and 18 months post-diagnosis were also associated significantly with OS. Receiving multiple forms of adjuvant treatment, a perception of not handling stress well and reporting one or more other major life events at six months post-diagnosis were factors associated with declines in QOL in multivariable analyses. Conclusions Interventions targeted at preventing QOL declines may ultimately improve quantity as well as quality of life following breast cancer. |
Formato |
application/pdf |
Identificador | |
Publicador |
John Wiley & Sons Ltd |
Relação |
http://eprints.qut.edu.au/33708/1/c33708.pdf DOI:10.1002/pon.1816 DiSipio, Tracey, Hayes, Sandi, Battistutta, Diana, Newman, Beth, & Janda, Monika (2011) Patterns, correlates, and prognostic significance of quality of life following breast cancer. Psycho-Oncology, 20(10), pp. 1084-1091. |
Direitos |
Copyright 2010 John Wiley & Sons Ltd. |
Fonte |
Faculty of Health; Institute of Health and Biomedical Innovation; School of Public Health & Social Work |
Palavras-Chave | #111299 Oncology and Carcinogenesis not elsewhere classified #breast cancer #quality of life #survival |
Tipo |
Journal Article |