Human osteoblast cell spreading and vinculin expression upon biomaterial surfaces


Autoria(s): Woodruff, Maria A.; Jones, Peter; Farrar, David; Grant, David; Scotchford, Colin
Data(s)

2007

Resumo

Any biomaterial implanted within the human body is influenced by the interactions that take place between its surface and the surrounding biological milieu. These interactions are known to influence the tissue interface dynamic, and thus act to emphasize the need to study cell-surface interactions as part of any biomaterial design process. The work described here investigates the relationship between human osteoblast attachment, spreading and focal contact formation on selected surfaces using immunostaining and digital image processing for vinculin, a key focal adhesion component. Our observations show that a relationship exists between levels of cell attachment, the degree of vinculin-associated plaque formation and biocompatibility. It also suggests that cell adhesion is not indicative of how supportive a substrate is to cell spreading, and that cell spreading

Identificador

http://eprints.qut.edu.au/32416/

Publicador

Springer Netherlands

Relação

DOI:10.1007/s10735-007-9142-1

Woodruff, Maria A., Jones, Peter, Farrar, David, Grant, David, & Scotchford, Colin (2007) Human osteoblast cell spreading and vinculin expression upon biomaterial surfaces. Journal of Molecular Histology, 38(5), pp. 491-499.

Direitos

Copyright 2007 Springer Netherlands

Fonte

Faculty of Built Environment and Engineering; Institute of Health and Biomedical Innovation

Palavras-Chave #090301 Biomaterials #osteoblast #bone #cell-surface
Tipo

Journal Article