In vitro and in vivo analysis of co-electrospun scaffolds made of medical grade poly(epsilon-caprolactone) and porcine collagen


Autoria(s): Chen, Z.C.; Ekaputra, A. K.; Gauthaman, K.; Adaikan, P.G.; Yu, H.; Hutmacher, D. W.
Data(s)

2008

Resumo

In this study, a nanofiber mesh made by co-electrospinning medical grade poly(epsilon-caprolactone) and collagen (mPCL/Col) was fabricated and studied. Its mechanical properties and characteristics were analyzed and compared to mPCL meshes. mPCL/Col meshes showed a reduction in strength but an increase in ductility when compared to PCL meshes. In vitro assays revealed that mPCL/Col supported the attachment and proliferation of smooth muscle cells on both sides of the mesh. In vivo studies in the corpus cavernosa of rabbits revealed that the mPCL/Col scaffold used in conjunction with autologous smooth muscle cells resulted in better integration with host tissue when compared to cell free scaffolds. On a cellular level preseeded scaffolds showed a minimized foreign body reaction.

Identificador

http://eprints.qut.edu.au/31019/

Publicador

VSP

Relação

DOI:10.1163/156856208784089580

Chen, Z.C., Ekaputra, A. K., Gauthaman, K., Adaikan, P.G., Yu, H., & Hutmacher, D. W. (2008) In vitro and in vivo analysis of co-electrospun scaffolds made of medical grade poly(epsilon-caprolactone) and porcine collagen. Journal of Biomaterials Science (Polymer Edition), 19(5), pp. 693-707.

Fonte

Faculty of Built Environment and Engineering; Institute of Health and Biomedical Innovation; School of Engineering Systems

Palavras-Chave #090301 Biomaterials #Cell Proliferation #Nanotechnology #Cell Adhesion
Tipo

Journal Article