The synthesis of novel isoindoline nitroxides bearing water-solubilising functionality


Autoria(s): Fairfull-Smith, Kathryn E.; Brackmann, Farina; Bottle, Steven E.
Data(s)

2009

Resumo

A range of novel tetramethyl- and tetraethylisoindolinenitroxides, possessing aryl-linked carboxylic acids, amines, alcohols and phosphonic acids were prepared. Notably, the chemistry established for the aromatic dibromination of the tetramethylisoindolines was not easily transferred to the corresponding tetraethylisoindoline system. Instead, various tetraethylisoindoline analogues were accessed by the oxidation of methyl groups attached to the aromatic ring to give the carboxylic acids. The increased steric bulk of the tetraethyl structures should limit bio-reduction and these compounds may have potential as antioxidants.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/29498/

Publicador

Wiley - VCH Verlag GmbH & Co. KGaA

Relação

http://eprints.qut.edu.au/29498/1/The_Synthesis_of_Novel_Isoindoline_Nitroxides_Bearing_Water_Solubilising_Functionality.pdf

DOI:10.1002/ejoc.200801255

Fairfull-Smith, Kathryn E., Brackmann, Farina, & Bottle, Steven E. (2009) The synthesis of novel isoindoline nitroxides bearing water-solubilising functionality. European Journal of Organic Chemistry, 2009(12), pp. 1902-1915.

Fonte

Faculty of Science and Technology; School of Physical & Chemical Sciences

Palavras-Chave #Nitroxide #Medicinal Chemistry #Antioxidant #Radicals #Isoindoline
Tipo

Journal Article