Tissue engineering of articular cartilage with biomimetic zones
Data(s) |
2009
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Resumo |
Articular cartilage damage is a persistent and increasing problem with the aging population, and treatments to achieve biological repair or restoration remain a challenge. Cartilage tissue engineering approaches have been investigated for over 20 years, but have yet to achieve the consistency and effectiveness for widespread clinical use. One of the potential reasons for this is that the engineered tissues do not have or establish the normal zonal organization of cells and extracellular matrix that appears critical for normal tissue function. A number of approaches are being taken currently to engineer tissue that more closely mimics the organization of native articular cartilage. This review focuses on the zonal organization of native articular cartilage, strategies being used to develop such organization, the reorganization that occurs after culture or implantation, and future prospects for the tissue engineering of articular cartilage with biomimetic zones. |
Identificador | |
Publicador |
Mary Ann Liebert |
Relação |
DOI:10.1089/ten.teb.2008.0563 Klein, Travis, Malda, Jos, Sah, Robert, & Hutmacher, Dietmar (2009) Tissue engineering of articular cartilage with biomimetic zones. Tissue Engineering, 15(2), pp. 143-157. |
Fonte |
Faculty of Built Environment and Engineering; Faculty of Science and Technology; Institute of Health and Biomedical Innovation; School of Life Sciences; School of Engineering Systems |
Palavras-Chave | #110322 Rheumatology and Arthritis #100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering) #Cartilage #Scaffold #Hydrogel #Regenerative Medicine #Tissue Engineering |
Tipo |
Journal Article |