992 resultados para transdermal delivery


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The summer trimester system provides students with greater flexibility to plan their study around work or lifestyle commitments, create options for students to commence a degree sooner or at a more convenient time of the year and enable students to fast track their study. There is increasing number of students enrolled in summer trimester. However, it was found that student engagement during summer is less than when those same subjects are delivered during other trimesters. This research investigates the using the "Sandwiches" delivery approach to improve the learning relationship with students. This innovative approach includes the first three weeks intensive oncampus delivery with a range of lectures and tutorials. This is followed by six weeks of on-line discussions, quizzes and self-assessment activities to strengthen the students' knowledge and reinforce learning. The last week of summer trimester is revision to confirm theory prior to an examination. Positive responses from student reflected that this approach can be used for other subjects not only in summer trimester but also applicable in other trimesters. In fact, In order to improve course delivery, higher education providers always collect feedback and comment from students and previous research studies have used various methodologies. This paper demonstrates how to use survey plus case study to analysis student satisfaction.

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Deakin University has recently moved to an academic calendar of three trimesters. This change aims to provide students with greater flexibility to plan their study around work or life commitments, create options for students to commence their degree and enable students to fast track their study. It has been found for students in the Bachelor of Construction Management that engagement and satisfaction during summer (Trimester 3) are less than when those same units are delivered during other trimesters. This research addresses the use of Supported Cloud learning to improve learning and the relationship with students. The School of Architecture and Built Environment used two units as case studies to examine different innovative unit delivery strategies that combined cloud and located learning. The research design included evaluation surveys, questionnaires, and semi-structured interviews as well as reflection by participating teachers. The findings show that students’ results are improved when the cloud based learning is supported by well-developed resources, structured delivery and availability of some face-to-face contacts. This innovation will serve as a benchmark for Cloud delivery in the School in all trimesters.

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Deakin University has recently moved to an academic calendar of three trimesters. This change aims to provide students with greater flexibility to plan their study around work or life commitments, create options for students to commence their degree and enable students to fast track their study. It has been found for students in the Bachelor of Construction Management that engagement and satisfaction during summer (Trimester 3) are less than when those same units are delivered during other trimesters. This research addresses the use of Supported Cloud learning to improve learning and the relationship with students. The School of Architecture and Built Environment used two units as case studies to examine different innovative unit delivery strategies that combined cloud and located learning. The research design included evaluation surveys, questionnaires, and semi-structured interviews as well as reflection by participating teachers. The findings show that students’ results are improved when the cloud based learning is supported by well-developed resources, structured delivery and availability of some face-to-face contacts. This innovation will serve as a benchmark for Cloud delivery in the School in all trimesters.

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Understanding the cellular target structure and thereby proposing the best delivery system to achieve sustained release of drugs has always been a significant area of focus in biomedical research for translational benefits. Specific targeting of the receptors expressed on the target cell represents an effective strategy for increasing the pharmacological efficacy of the administered drug. Liposomes offer enhanced conveyance as a potential carrier of biomacromolecules such as anti-cancer proteins, drugs and siRNA for targeting tumour cell death. Commonly used liposomal constructs for various therapies are Doxil, Myocet, DepoCyt and Abraxanes. However, recent strategy of using multifunctional liposomes for the sustained release of drugs with increased plasma residence time and monoclonal antibody-based targeting of tumours coupled with imaging modalities have attracted enormous scientific attention. The ability of liposomes coated with specific ligands such as Apo-E derived RGD R9 and Tat peptide, to reverse the conceptualisation of drug resistance and cross the blood brain barrier, provides promising future for their use as an efficient drug delivery system. By outlining the recent advancements and innovations in the established concept of liposomal drug delivery, this review will focus on the multifunctional liposomes as an emerging novel lipid based drug delivery system.

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The recurrence and metastatic spread of cancer are major drawbacks in cancer treatment. Although chemotherapy is one of the most effective methods for the treatment of metastatic cancers, it is nonspecific and causes significant toxic damage. The development of drug resistance to chemotherapeutic agents through various mechanisms also limits their therapeutic potential. However, as we discuss here, the use of nanodelivery systems that are a combination of diagnostics and therapeutics (theranostics) is as relatively novel concept in the treatment of cancer. Such systems are likely to improve the therapeutic benefits of encapsulated drugs and can transit to the desired site, maintaining their pharmaceutical properties. The specific targeting of malignant cells using multifunctional nanoparticles exploits theranostics as an improved agent for delivering anticancer drugs and as a new solution for overriding drug resistance.

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A significant number of Australian universities have multiple campuses (Winchester and Sterk 2006). To manage successful student learning outcomes, Winchester and Sterk (2006) argue that universities may experience challenging teaching and learning issues such as fragmentation, duplication, inconsistency and lack of equitable opportunities for students across the various sites. In recent years, online educational technology has enabled Australian universities to rethink the ways in which they deliver programmes (Smith, Ling and Hill 2006). Such a paradigm and technological shift provide a ‘window of opportunity’ to meet the challenging demands of serving multiple campuses (Bottomley 2000), especially those in regional areas. In Victoria, at June 2012, the regional population was 1.38 million (Australian Bureau of Statistics 2013). However, Polesel’s (2009) report found that students from regional areas defer university at twice the rate of metropolitan students. There is also evidence that students in regional areas, on the one hand, consider such areas as a learning environment with many advantages (e.g. small classes and a compact campus)(Ellis et al. 2005). On the other hand, students’ different interests can often be overlooked in educational settings (Semke and Sheridan 2012).
This paper will report on the results of a baseline study using survey methodology, which examined the challenges and opportunities of delivering elements of two undergraduate programmes in regional areas in Victoria, Australia. In particular, the research focused on two selected undergraduate teacher education programmes: (1) primary education; and (2) early childhood education. Focused discussion data, gathered from academics involved in delivering the programmes in the regional campuses will be presented as an analysis of issues and practices of teaching and learning in the 21st century. Implications for the provision of a quality learning experience and environment for students and for the course marketing strategies will be discussed.

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A library of novel amphiphiles were designed and synthesised, towards self-assembly based drug delivery for the treatment of breast cancer. The amphiphiles were formulated into liposomes of varying size and shape, and showed promising potential for drug delivery. Active targeting of breast cancer tumours was also explored with promising results.

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Background
Renal access coordinators contribute specifically to dialysis access care for people with chronic and end stage renal disease. Since the introduction of renal access coordinators into Australia in the early 2000s, there have been anecdotal examples of associated improvements in patient outcomes and service delivery; however scant published quantitative evidence exists. Thus, the impact of the implementation of renal access coordinators has not undergone a rigorous review to date.

Objective
The objective of this systematic review was to critically appraise and synthesize the best available evidence related to the impact of renal access coordinators on dialysis patient outcomes and associated service delivery.

INCLUSION CRITERIA

Types of participants

This review considered studies that included renal access coordinators (noting variations of the titles) and adult hemodialysis patients (aged 18 years and over).

Types of intervention(s)
This review considered studies that evaluated the effectiveness of the renal access coordinator. This role typically consists of clinical and administration duties such as providing pre dialysis access coordination, access surveillance patient education and nurse education.

Types of studies
The types of studies considered within this review included experimental and epidemiological study designs. Thus randomized controlled trials (RCT), non-randomized controlled trials, and quasi-experimental, before and after studies, prospective and retrospective cohort studies were considered as were case control studies, analytical cross sectional studies and descriptive cross sectional studies.

Types of outcomes

Patient outcomes considered included: days to first vascular access complication (such as stenosis or thrombosis) and/or primary intervention (such as angioplasty or surgical intervention); percentage of central line insertions (negative); rate of arteriovenous fistula (AVF)/arteriovenous graft (AVG)/central venous catheter (CVC) at start of dialysis (incidence); prevalent rate of AVF/AVG/CVC; time to occlusion of AVF and time from referral to surgery. Service outcomes included: knowledge/up skilling of renal nurses; cannulation skills, ultrasound skills, knowledge of anatomy and physiology and other access related knowledge.

Search strategy
The search strategy aimed to locate published and unpublished studies, utilizing a three-step searching approach. Studies published in English from 1990 to October 2013 were considered for inclusion in this review.

Methodological quality
The studies were assessed by two independent reviewers using the appropriate standardized critical appraisal instruments from the Joanna Briggs Institute.

Data collection

Data were extracted from papers included in the review using the standardised data extraction tool from the Joanna Briggs Institute, namely JBI Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI).

Data synthesis
This review aimed to conduct meta-analyses of the findings: however, because of the limitations of the data found, this was not possible and so the findings are presented in a narrative format.

Results
Five studies were identified for inclusion in the review. No RCTs were found, therefore four of the five studies were pre-post intervention cohort studies and one was a prospective quality assurance report. Data were heterogeneous and thus did not allow for meta-analysis. All studies included multidisciplinary teams with variable emphasis on the renal access coordinator role. The pre post intervention cohort studies measured incident and/or prevalent AVF, AVG and CVC rates in the hemodialysis population and the quality assurance report measured the difference in patency rates between AVF and AVG. All discussed the role of central coordination as a contributor to the success of vascular access care.

Conclusions
This review found insufficient data to make firm conclusions about the impact that renal access coordinators have on patient outcomes. The results of this review suggest an association between renal access coordinators and improved patient outcomes. These improved patient outcomes were apparent in an increase in incident and prevalent AVFs, and a decrease in the incidence and prevalence of CVCs. Both associations are correlated with a reduction in infection rates, length of hospital stay and healthcare costs.

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Hepatology and gastroenterology services are increasingly utilising the skills and experience of nurse practitioners and nurse specialists to help meet the increasing demand for health care. A new nurse-led assessment clinic has been established in the liver clinic at Geelong Hospital to utilise the expertise of nurses to assess and triage new patients and streamline their pathway through the health care system. The aim of this study is to quantitatively assess the first two years of operation of the nurse assessment clinic at Geelong Hospital, and to assess advantages and disadvantages of the nurse-led clinic. Data was extracted retrospectively from clinical records of new patients at the liver clinic. Quarterly one-month periods were recorded over two-years. Patients were categorised according to the path via which they saw a physician, including missed and rescheduled appointments. The number of appointments, the waiting time from referral to appointments and the number of ‘did-not-attend’ occasions were analysed before and after the institution of the nurse-led assessment clinic. The Mann-Whitney rank sum test of ordinal data was used to generate median wait times. There was shown to be a statistically significant longer waiting time for physician appointment if seen by the nurse first. The difference in waiting time was 10 days. However, there was also a reduction in the number of missed appointments at the subsequent physician clinic. Other advantages have also been identified including effective triage of patients, and organisation of appropriate investigations from the initial nurse assessment.