Laws of the State of Maine, volumes 1 and 2 : with the constitution of the U. States and of said state, prefixed : also, notes and references, delineating the additions and modifications thereof, which have been enacted ... from 1821 to 1834 : to which are appended ... a full synopsis of the decisions relating thereto, contained in the 17 volumes of Massachusetts reports, 10 volumes Pickering's Reports, and 7 volumes of Greenleaf's Reports /

Includes index.

The history of the rebellion and civil wars in England, begun in the year 1641. : With the precedent passages, and actions, that contributed thereunto, and the happy end, and conclusion thereof by the King's blessed restoration, and return, upon the 29th of May, in the year 1660. /

According to Lowndes the edition of 1731 known as the "Masters' ed." was illustrated, but the plates, portraits, and maps are the same as those issued in The Lord Clarendon's History of the Grand Rebellion Compleated. London, 1717.

Barker's delight: or, The art of angling. Wherein are discovered many rare secrets very necessary to be known by all that delight in that recreation, both for catching the fish, and dressing thereof.

On cover: Reprinted from the original edition of 1657, for E. Bryant, 1826.

The Doctrine of eternal hell torments overthrown. In three parts. 1. Of the torments of hell, the foundation and pillars thereof searched, discovered, shaked and removed, etc. [by Samuel Richardson]. 2. An article from the Harleian miscellany on Universalism. 3. Dr. Hartley's defence of Universalism.

Copyright by Thomas Whittemore.

Christologia, or, A declaration of the glorious mystery of the person of Christ, God and man : with the infinite wisdom, love and power of God in the contrivance and constitution thereof; as also of the grounds and reasons of his incarnation, the nature of his ministry in heaven, the present state of the church above thereon, and the use of his person in religion; with an account and vindication of the honour, worship, faith, love and obedience due unto him, in and from the church /

Bound with: Meditations and discourses on the glory of Christ / by John Owen.

Regulation of railway rates. Appendix D. Hearings before the Committee on Interstate Commerce, United States Senate, in special session, pursuant to Senate resloution no, 288, Fifty-eighth Congress, third session. Response of the Interstate Commercs Commission to the senate resolution of January 16, 1905, calling for facts and information concerning complaints and cases brought before the commission and the courts involving violations of the act to regulate commerce and amendments thereof. May 3, 1905.

Mode of access: Internet.

A briefe discourse of the Nevv-found-land : with the situation, temperature, and commodities thereof, inciting our nations to goe forward in that hopefull plantation begunne.

Mode of access: Internet.

Health care costs and lack of access to health insurance : hearings before the Committee on Finance, United States Senate, One Hundred Second Congress, first session.

"April 9 and 16, 1991"--Pt. 1; "June 6, 1991"--Pt. 2.

Income tax : a concise exposition of the law and practice thereof ; with instructions as to filling up and returning the necessary forms to which is prefixed a short thesis on direct and indirect taxation with forms /

Includes index.

Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice

Spinal cord injury usually results in permanent paralysis because of lack of regrowth of damaged neurons. Here we demonstrate that adult mice lacking EphA4 (-/-), a molecule essential for correct guidance of spinal cord axons during development, exhibit axonal regeneration and functional recovery after spinal cord hemisection. Anterograde and retrograde tracing showed that axons from multiple pathways, including corticospinal and rubrospinal tracts, crossed the lesion site. EphA4 -/- mice recovered stride length, the ability to walk on and climb a grid, and the ability to grasp with the affected hindpaw within 1-3 months of injury. EphA4 expression was upregulated on astrocytes at the lesion site in wild-type mice, whereas astrocytic gliosis and the glial scar were greatly reduced in lesioned EphA4-/- spinal cords. EphA4 -/- astrocytes failed to respond to the inflammatory cytokines, interferon-gamma or leukemia inhibitory factor, in vitro. Neurons grown on wild-type astrocytes extended shorter neurites than on EphA4 -/- astrocytes, but longer neurites when the astrocyte EphA4 was blocked by monomeric EphrinA5-Fc. Thus, EphA4 regulates two important features of spinal cord injury, axonal inhibition, and astrocytic gliosis.

EGFR amplification and lack of activating mutations in metaplastic breast carcinomas

Metaplastic breast carcinomas are reported to harbour epidermal growth factor receptor (EGFR) overexpression in up to 80% of the cases, but EGFR gene amplification is the underlying genetic mechanism in around one-third of these. In this study, EGFR gene amplification as defined by chromogenic in situ hybridization and protein overexpression was examined in a cohort of 47 metaplastic breast carcinomas. Furthermore, the presence of activating EGFR mutations in exons 18, 19, 20, and 21 was investigated. Thirty-two cases showed EGFR overexpression and of these, 11 (34%) harboured EGFR gene amplification. In addition, EGFR amplification showed a statistically significant association with EGFR overexpression (p < 0.0094) and was restricted to carcinomas with homologous metaplasia. Ten cases, five with and five without EGFR amplification, were subjected to microarray-based CGH, which demonstrated that EGFR copy number gain may occur by amplification of a discrete genomic region or by gains of the short arm of chromosome 7 with a breakpoint near the EGFR gene locus, the minimal region of amplification mapping to EGFR, LANCL2, and SECOG. No activating EGFR mutations were identified, suggesting that this is unlikely to be a common alternative underlying genetic mechanism for EGFR expression in metaplastic breast carcinomas. Given that metaplastic breast carcinomas are resistant to conventional chemotherapy or hormone therapy regimens and that tumours with EGFR amplification are reported to be sensitive to EGFR tyrosine kinase inhibitors, these findings indicate that further studies are warranted to explore EGFR tyrosine kinase inhibitors as potential therapeutic agents for metaplastic breast carcinomas harbouring amplification of 7p11.2. Copyright (c) 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd

Prostate cancer markers and uses thereof

The present invention relates to composition and methods of cancer diagnosis, research and therapy including, but not limited to, cancer markers. In particular, the present invention relates to LRG1 protein markers for use in the diagnosis, prognosis and determination of treatment of prostate cancer.

METAMATERIAL DEVICE AND USES THEREOF

The present invention relates to a logic gate, comprising a metamaterial surface enhanced Raman scattering (MetaSERS) sensor, comprising (a) alphabetical metamaterials in the form of split ring resonators operating in the wavelength range of from 560 to 2200 nm; and (b) a guanine (G) and thymine (T)-rich oligonucleotide that can, upon presence of potassium cations (K+), fold into a G-quadruplex structure, and in presence of Hg2+, form a T-Hg2+-T hairpin complex that inhibits or disrupts the G-quadruplex structure formed in presence of K+, as well as methods of operating and using such a logic gate.

Stable isotope record of planktonic foraminifera of the South Atlantic

The central problem of late Quaternary circulation in the South Atlantic is its role in transfer of heat to the North Atlantic, as this modifies amplitude, and perhaps phase, of glacialinterglacial fluctuations. Here we attempt to define the problem and establish ways to attack it. We identify several crucial elements in the dynamics of heat export: (1) warm-water pile-up (and lack thereof) in the Western equatorial Atlantic, (2) general spin-up (or spin-down) of central gyre, tied to SE trades, (3) opening and closing of Cape Valve (Agulhas retroflection), (4) deepwater E-W asymmetry. Means for reconstruction are biogeography, stable isotopes, and productivity proxies. Main results concern overall glacial-interglacial contrast (less pile-up, more spin-up, Cape Valve closed, less NADW during glacial time), dominance of precessional signal in tropics, phase shifts in precessional response. To generate working hypotheses about the dynamics of surface water circulation in the South Atlantic we employ Croll's paradigm that glacial - interglacial fluctuations are analogous to seasonal fluctuations. Our general picture for the last 300 kyrs is that, as concerns the South Atlantic, intensity of surface water (heat) transport depends on the strength of the SE trades. From various lines of evidence it appears that strenger SE trades appeared during glacials and cold substages during interglacials, analogous to conditions in southern winter (August).