Caractérisation des interactions d'inhibiteurs de l'entrée du VIH dans un modèle de cellules dendritiques in vitro

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Caractérisation des interactions d'inhibiteurs de l'entrée du VIH dans un modèle de cellules dendritiques in vitro

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

L'Archiviste : revue historique et documentaire publiée d'après des documents tirés des collections publiques et privées de la France et de l'étranger / sous la direction de L. Séché

1892/12 (T1,N1)-1893/06 (T1,N9).

L'Archiviste : revue historique et documentaire publiée d'après des documents tirés des collections publiques et privées de la France et de l'étranger / sous la direction de L. Séché

1893/07 (T2,N10)-1893/10 (T2,N13).

Geologische Beschreibung des Kantons St. Gallen und seiner umgebungen Enthalten auf Blatt IX des eidg. Atlas mit Benutzung des Nachlasses von A. Escher v. d. Linth bearb. von Reallehrer Gutzwiller, prof. Kaufmann, dr. Cas. Mösch.

Each vol. has also special t.p.

Těsnopisecká zpráva o I. schůzi Národního shroḿždění československého v Praze dne 14. listopadu 1918.

Mode of access: Internet.

The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models

Colorectal cancer is the second most common cause of cancer-related death in the United States. Recent studies showed that interleukin-8 (IL-8) and its receptors (CXCR1 and CXCR2) are significantly upregulated in both the tumor and its microenvironment, and act as key regulators of proliferation, angiogenesis, and metastasis. Our previous study showed that IL-8 overexpression in colorectal cancer cells triggers the upregulation of the CXCR2-mediated proliferative pathway. The aim of this study was to investigate whether the CXCR2 antagonist, SCH-527123, inhibits colorectal cancer proliferation and if it can sensitize colorectal cancer cells to oxaliplatin both in vitro and in vivo. SCH-527123 showed concentration-dependent antiproliferative effects in HCT116, Caco2, and their respective IL-8-overexpressing variants colorectal cancer cell lines. Moreover, SCH-527123 was able to suppress CXCR2-mediated signal transduction as shown through decreased phosphorylation of the NF-κB/mitogen-activated protein kinase (MAPK)/AKT pathway. These findings corresponded with decreased cell migration and invasion, while increased apoptosis in colorectal cancer cell lines. In vivo results verified that SCH-527123 treatment decreased tumor growth and microvessel density when compared with vehicle-treated tumors. Importantly, these preclinical studies showed that the combination of SCH-527123 and oxaliplatin resulted in a greater decrease in cell proliferation, tumor growth, apoptosis, and angiogenesis that was superior to single-agent treatment. Taken together, these findings suggest that targeting CXCR2 may block tumor proliferation, migration, invasion, and angiogenesis. In addition, CXCR2 blockade may further sensitize colorectal cancer to oxaliplatin treatment.

Ethanol-induced sensitization depends preferentially on D(1) rather than D(2) dopamine receptors

Behavioral sensitization, defined as a progressive increase in the locomotor stimulant effects elicited by repeated exposure to drugs of abuse, has been used as an animal model for drug craving in humans. The mesoaccumbens dopaminergic system has been proposed to be critically involved in this phenomenon; however, few studies have been designed to systematically investigate the effects of dopaminergic antagonists on development and expression of behavioral sensitization to ethanol in Swiss mice. We first tested the effects of D(1) antagonist SCH-23390 (0-0.03 mg/kg) or D(2) antagonist Sulpiride (0-30 mg/kg) on the locomotor responses to an acute injection of ethanol (2.0 g/kg). Results showed that all tested doses of the antagonists were effective in blocking ethanol`s stimulant effects. In another set of experiments, mice were pretreated intraperitoneally with SCH-23390 (0.01 mg/kg) or Sulpiride (10 mg/kg) 30 min before saline or ethanol injection, for 21 days. Locomotor activity was measured weekly for 20 min. Four days following this pretreatment, all mice were challenged with ethanol. Both antagonists attenuated the development of ethanol sensitization, but only SCH-23390 blocked the expression of ethanol sensitization according to this protocol. When we tested a single dose (30 min before tests) of either antagonist in mice treated chronically with ethanol, both antagonists attenuated ethanol-induced effects. The present findings demonstrate that the concomitant administration of ethanol with D(1) but not D(2) antagonist prevented the expression of ethanol sensitization, suggesting that the neuroadaptations underlying ethanol behavioral sensitization depend preferentially on D(1) receptor actions. (C) 2010 Elsevier Inc. All rights reserved.

Cartas eclesiásticas de D. Joaquin Lorenzo Villanueva al doctor D. Guillermo Diaz Luzeredi : en defensa de las leyes que autorizan ahora al pueblo para que lea en su lengua la Sagrada Escritura : va al principio una Carta del Rmo. P. Felipe Scio de S. Miguel ... á este mismo propósito

Guillermo Diaz Luzeredi es seudónimo de Miguel Elizalde Urdiroz

Propositiones theologiae scholasticae, dogmaticae, polemicae ex D. Thomae Aquinatis ... quatuor summae partibus desumtos [Texto impreso]

Viñeta en port

Propositiones theologiae scholasticae, dogmaticae, polemicae, ex D. Thomae Aquinatis... quatuor summae partibus desuntas [Texto impreso]

Viñeta en port

Les Annales romantiques; revue d'histoire du romantisme.

Editor: June 1904- Léon Séché.