Crönungs-Handlung : Eygendliche Abbild- vnd Erklärung, welcher gestalt die AllerDurchleuchtigste, Großmächtigste Fürstin vnd Fraw, Fraw Eleonora, Röm. Käyserin, in Germanien, zu Hungarn vnnd Böheim Königin ... den 7. Novemb. ... deß 1630. Jahres, bey endung deß Churfürstlichen Collegial-Tags, in Regenspurg zur Römischen Käyserin solenniter gekrönet worden

Abgezeichnet, in Kupffer gebracht vnd zu finden bey Johann Hauer Mahlern vnd Kunsthändlern in Nürnberg

Akiba : Ein palästinensischer Gelehrter aus dem zweiten nachchristlichen Jahrhundert ; ein Beitrag z. röm.-judäischen Geschichte nach den zeitgenössischen Quellen dargest.

Jena, Univ., Diss.

Der hinckend und stolpernd, doch eilfertig, fliegend und laufende Reichs-Bott : das ist evangelisch-verbesserter, catholisch-neuer und alter julianischer röm. kayserl. europäischer Reichs-, Staats-, Kriegs-, Siegs- und Geschichts-Kalender auf das Jahr nach gnadenreicher Geburt Jesu Christi ...

Der hinckende Bot

Furier vnd Futterzettel, Deß Durchleuchtigsten, Hochgebornen Fürsten vnd Herrn, Herren Johann Sigismunden, Marggraffen zu Brandenburg, deß H. Röm. Reichs Ertzkämmerern und Churfürsten ... zu dem angesetzten Wahltag gen Franckfurt am Mayn abgeordneten Herrn Gesandten und Rähten, den 11/21 Maii, 1612. ankommen : Item ihrer Churf. G. Marggraff Georg Wilhelms ihrer Churf. G. jungen Herrns Hoffstatt, Sampt Deß auch Durchleuchtigsten, Hochgebornen Fürsten und Herrns, Herrn Joachim Ernsten, Marggraffen zu Brandenburg, [et]c. Hoffstatt. Wie dieselbe sampt den Ihrigen ansehnlichen Comitat, nach dem Wahltag zur Königlichen Krönung eingeritten und erschienen

Gelegenheitsschrift zur Wahl und Krönung von Matthias zum Römisch-Deutschen Kaiser

Furierzettel, Deß Hochwürdigsten in Gott Vatters, und Durchleuchtigsten Fürsten und Herrn, Herrn Ferdinanden, Ertzbischoffen zu Cölln, deß H. Röm. Reichs durch Italien Ertz-Cantzlern, und Churfürsten ... auff den Wahltag gen Franckfurt den 10/20. Maii, Anno 1612.

Gelegenheitsschrift zur Wahl und Krönung von Matthias zum Römisch-Deutschen Kaiser

Decomposition of $\rm R\times C$ contingency table chi -square: Application to binned DNA fragment size data and population structure analysis

The purpose of this research is to develop a new statistical method to determine the minimum set of rows (R) in a R x C contingency table of discrete data that explains the dependence of observations. The statistical power of the method will be empirically determined by computer simulation to judge its efficiency over the presently existing methods. The method will be applied to data on DNA fragment length variation at six VNTR loci in over 72 populations from five major racial groups of human (total sample size is over 15,000 individuals; each sample having at least 50 individuals). DNA fragment lengths grouped in bins will form the basis of studying inter-population DNA variation within the racial groups are significant, will provide a rigorous re-binning procedure for forensic computation of DNA profile frequencies that takes into account intra-racial DNA variation among populations. ^

Modulation of BCL-X$\sb{\rm L}$ is a critical determinant of c-myc induced apoptosis

The fine balance between proliferation and apoptosis plays a primary role in carcinogenesis. Proto-oncogenes that induce both proliferation and apoptosis provide a powerful inbuilt system to inhibit clonal expansion of cells with high proliferation rates. This provides a restraint to the development of neoplasms. C-myc expressing cells undergo apoptosis in low serum by an unknown mechanism. Several lines of evidence suggested that c-myc induces apoptosis by a transcriptional mechanism. However, the target genes of this program have not been fully defined. Protein synthesis inhibitors induce apoptosis in c-myc over-expressing cells at high serum levels suggesting that inhibition of synthesis of a survival factor may induce apoptosis. We show that the expression of c-myc directly correlates with an increase in the level of a survival protein, bcl-$\rm x\sb{L},$ and a decrease in the pro-apoptotic protein, bax, at both the protein and mRNA level. Furthermore, a significant decrease of the bcl-$\rm x\sb{L}$ protein levels is observed under low serum conditions. In order to investigate the mechanism of regulation of bcl-$\rm x\sb{L}$ and bax by c-myc, the bcl-x and bax promoters were cloned, sequenced and shown to contain c-myc binding sites. The chloramephenicol acetyl transferase (CAT) reporter assay was used to demonstrate activation of the bcl-x promoter by increasing levels of c-myc when co-transfected in COS cells. The bax promoter was also shown to be transrepressed in c-myc expressing cells. The role of bcl-$\rm x\sb{L}$ in apoptosis regulation in c-myc cell lines in normal and low serum was then investigated. Cells lines expressing c-myc and bcl-$\rm x\sb{L}$ were generated and were shown to be resistant to apoptosis induction in low serum. Furthermore, cell lines expressing c-myc, anti-sense bcl-$\rm x\sb{L}$ and $\beta$-galactosidase demonstrated significantly enhanced rates of apoptosis in high serum compared to c-myc Rat 1a cells. These findings suggest that c-myc activates a survival program involving bcl-$\rm x\sb{L}$ upregulation and bax downregulation. However, this survival signal is reduced under low serum conditions by the relative downregulation of bcl-$\rm x\sb{L}$ allowing for apoptosis to proceed. These data also directly demonstrates that downregulation in the level of bcl-$\rm x\sb{L}$ associated with low serum conditions is a critical determinant of c-myc induced apoptosis. ^