Simulation of the postoperative trunk appearance in scoliosis surgery

Persistence of external trunk asymmetry after scoliosis surgical treatment is frequent and difficult to predict by clinicians. This is a significant problem considering that correction of the apparent deformity is a major factor of satisfaction for the patients. A simulation of the correction on the external appearance would allow the clinician to illustrate to the patient the potential result of the surgery and would help in deciding on a surgical strategy that could most improve his/her appearance. We describe a method to predict the scoliotic trunk shape after a spine surgical intervention. The capability of our method was evaluated using real data of scoliotic patients. Results of the qualitative evaluation were very promising and a quantitative evaluation based on the comparison of the simulated and the actual postoperative trunk surface showed an adequate accuracy for clinical assessment. The required short simulation time also makes our approach an eligible candidate for a clinical environment demanding interactive simulations.

Suivi longitudinal de la densité osseuse et du statut en vitamine D chez des enfants prépubères avec une allergie au lait de vache non résolue.

Problématique : L'allergie au lait de vache (ALV) est reconnue comme une condition transitoire qui disparaît chez la majorité des enfants avant l’âge de 3-5 ans, mais des données récentes révèlent une persistance de l’ALV. Les enfants souffrant d’une ALV sont à risque d’apports insuffisants en calcium et en vitamine D, deux nutriments impliqués dans la santé osseuse. Une première étude transversale portant sur la santé osseuse d’enfants prépubères ALV a observé que la densité osseuse (DMO) lombaire était significativement inférieure à celle d’enfants sans allergie au lait de vache (SALV). Objectifs : Sur la base de ces résultats, nous désirons documenter l’évolution longitudinale de la santé osseuse, du statut en vitamine D, des apports en calcium et en vitamine D et de l’adhérence à la supplémentation des enfants ALV (n=36) et de comparer ces données aux enfants SALV (n=19). Résultats : Le gain annualisé de la DMO lombaire est similaire entre les enfants ALV et SALV. Bien qu’il n’y ait pas de différence significative entre les deux groupes, la DMO lombaire des enfants ALV demeure cependant inférieure à celle des témoins. Qui plus est, le score-Z de la DMO du corps entier tend à être inférieur chez les enfants-cas comparé aux témoins. Au suivi, la concentration de 25OHD et le taux d’insuffisance en vitamine D sont similaires entre les deux groupes tout comme les apports en calcium et en vitamine D. Davantage d’enfants ALV prennent un supplément de calcium au suivi comparativement au temps initial (42% vs. 49%, p<0,05), mais le taux d’adhérence à la supplémentation a diminué à 4 jours/semaine. Conclusion : Une évaluation plus précoce ainsi qu’une prise en charge de la santé osseuse des enfants ALV pourraient être indiquées afin de modifier l’évolution naturelle de leur santé osseuse. Les résultats justifient aussi le suivi étroit des apports en calcium et vitamine D par une nutritionniste et la nécessité d'intégrer la supplémentation dans le plan de traitement de ces enfants et d’assurer une surveillance de l’adhérence à la supplémentation.

Qui utilise 10% de son cerveau?

Ce texte examine la croyance largement répandue selon laquelle les humains n'utiliseraient que 10 % de leur cerveau. Le texte comprend quatre parties. Les deux premières parties évaluent l'ampleur du «mythe du 10 %» et en retracent les origines. La troisième partie montre que cette croyance n'est nullement justifiée en passant successivement en revue les connaissances concernant l'anatomie et la physiologie du cerveau, la plasticité cérébrale ainsi que des données sur l'évolution. La dernière partie évoque quelques raisons de la persistance du mythe du 10 %.

Gamma stochastic volatility models

This paper presents gamma stochastic volatility models and investigates its distributional and time series properties. The parameter estimators obtained by the method of moments are shown analytically to be consistent and asymptotically normal. The simulation results indicate that the estimators behave well. The insample analysis shows that return models with gamma autoregressive stochastic volatility processes capture the leptokurtic nature of return distributions and the slowly decaying autocorrelation functions of squared stock index returns for the USA and UK. In comparison with GARCH and EGARCH models, the gamma autoregressive model picks up the persistence in volatility for the US and UK index returns but not the volatility persistence for the Canadian and Japanese index returns. The out-of-sample analysis indicates that the gamma autoregressive model has a superior volatility forecasting performance compared to GARCH and EGARCH models.

Biochemical effects of the pesticide Chlorpyrifos on the fish Oreochromis mossambicus (Peters)

Man uses a variety of synthetic material for his comfortable materialistic life. Thus human interactions may become harmful for various terrestrial and aquatic lives. This is by contaminating their habitat and by becoming a threat to organisms itself. Thus the application and dispersal of several organic pollutants can lead to the development of several mutated forms of the species when exposed to sublethal concentrations of the pollutants. Otherwise, a decrease in number or extinction of these exposed species from earth's face may happen. Pesticides, we use for the benefit of crop yield, but its persistence may become havoc to non-target organism. Pesticides reaching a reservoir can subsequently enter the higher trophic levels. Organophosphorus compounds have replaced all other pesticides, due to its acute toxicity and non-persistent nature.Hence the present study has concentrated on the toxicity of the largest market-selling and multipurpose pesticide, chlorpyrifos on the commonly edible aquatic organism, fish. The euryhaline cichlid Oreochromis mossambicus was selected as animal model. The study has concentrated on investigating biochemical parameters like tissue-specific enzymes, antioxidant and lipid-peroxidation parameters, haematological and histological observations and pesticide residue analysis.Major findings of this work have indicated the possibility of aquatic toxicity to the fish on exposure to the insecticide chlorpyrifos. The insecticide was found as effective to induce structural alteration, depletion in protein content, decrease in different metabolic enzyme levels and to progress lipid peroxidation on a prolonged exposure of 21 days. The ion-transport mechanism was found to be adversely affected. Electrophoretic analysis revealed the disappearance of several protein bands after 21days of exposure to chlorpyrifos. Residue, analysis by gas chromatography explored the levels of chlorpyrifos retaining on the edible tissue portions during exposure period of 21days and also on a recovery period of 10 days.

Dynamics Of Pesticides In The Backwaters Of Kuttanad

The tremendous growth in industrial production and the consequent improving in the standards of living have provoked worldwide discussion on environmental quality. The question of abusive use of pesticides for crop protection and vector control programmes is only one aspect of this entire complex. Inspite of this, tendentious publications such as Rachel Carson’s Silent spring have brought crop protection into the foreground of environmental discussions. The persistence and high stability of organochlorine pesticides are regarded as problematic and the accumulation of pesticides residues and its metabolites in the different compartments of the environment is one of the major concerns. Because of their persistence in the aquatic environment and biomagnifications in food chain, the continuous use of pesticides will have wider implications not only in aquatic environmental quality but also on human health. The residual levels of these persistent chemicals exceed their permissible limits, and get partitioned among the constituent phases of the aquatic systems. Crop protection is only part of the agricultural economy and in agriculture itself has led to the most fundamental changes in the human environment. So, in all areas of life one must weigh the desired advantages against possible disadvantages. The proposed thesis is based on the investigations on the distributions of organochlorine and organophosphorus pesticides in the waters and sediments of Kuttanad backwaters. Kuttanad, a unique agricultural area, which forms the southern part of the Vembanad lake, is a deltaic formation of four river systems entering the southern part of the Cochin estuary. No systematic study has ever been done to assess the ecotoxicological impact of these diverse chemicals and their metabolites in Kuttanad area. So, a detailed systematic and rigorous investigation on the distributions of these persistent chemicals is carried out. The thesis is divided into 7 Chapters

Phase Transitions Of Trace Metals In The Aquatic Environment Of Kuttanad, Kerala

Environmental persistence, fate and interactive effects with living organisms - beneficial or toxic - of trace elements are directly related to the physico-chemical forms in which they occur. Knowledge on the association of trace metals with different environmental compartments in an aquatic system are, therefore, essential for monitoring the trace metal pollution as well as transport, fate and bio-geochemical cycles of trace metals. This thesis is a modest attempt in assessing the trace metal levels and their behaviour in the aquatic environment of Kuttanad, an aquatic system that is severely affected by man's intervention on natural processes, by seriously evaluating the levels of trace metals in dissolved and particulate phases and also in the different chemical fractions of the sediments.

Studies on the toxic effects of selected heavy metals in the freshwater mussel lamellidens corrianus (lea)

Industrialisation affects air, water, and soil. Industrial effluents which enter the aquatic environment either by direct disposal or through run off, affect living organisms at morphological and physiological levels. In any living tissue toxic materials exert their effects first at molecular and biochemical levels (Robbins and Angell, 1976). Most of the industrial effluents contain elevated concentrations of organic and inorganic chemicals capable of eliciting stimulatory or inhibitory effects on the metabolism of aquatic organisms. Heavy metals form an important group of environmental pollutants. Effects of pollution on the aquatic environment by heavy metals have received considerable attention in recent years due to their toxicity even at very low levels, persistence in the environment, and chances of getting biomagnified. A pollutant that does not affect a particular process under normal unstressed condition may affect the ability of the animal to adjust to changing environmental conditions which ultimately decrease its chances of survival (Thurberg et al., 1973

An inhibitory compound produced by Pseudomonas with effectiveness on Vibrio harveyi

Persistence of the antivibrio property of the potential antagonistic probiotics, Pseudomonas MCCB 102 and 103, at di¡erent temperatures, pH and in organic solvents was studied. The antivibrio compound was extracted, puri¢ed and characterized using thin-layer chromatography, high-pressure liquid chromatography, liquid chromatography-mass spectroscopy, UV^ Vis and nuclear magnetic resonance spectroscopy and identi¢ed as N-methyl-1-hydroxyphenazine, a phenazine antibiotic. The toxicity of the compound was tested in Penaeus monodon haemocyte culture and the IC50 valuewas found to be1.4 0.31mg L 1. The compound was found to be bacteriostatic at 0.5mg L 1. Its stability to varying temperature, pH, organic solvents, prolonged shelf-life and vibriostatic nature point to its suitability for prophylatic aquaculture application.

Molecular mechanisms controlling the precision of chemokine guided cell migration

By the end of the first day of embryonic development, zebrafish primordial germ cells (PGCs) arrive at the site where the gonad develops. In our study we investigated the mechanisms controlling the precision of primordial germ cell arrival at their target. We found that in contrast with our expectations which were based on findings in Drosophila and mouse, the endoderm does not constitute a preferred migration substrate for the PGCs. Rather, endoderm derivatives are important for later stages of organogenesis keeping the PGC clusters separated. It would be interesting to investigate the precise mechanism by which endoderm controls germ cell position in the gonad. In their migration towards the gonad, zebrafish germ cells follow the gradient of chemokine SDF-1a, which they detect using the receptor CXCR4b that is expressed on their membrane. Here we show that the C-terminal region of CXCR4b is responsible for down-regulation of receptor activity as well as for receptor internalization. We demonstrate that receptor molecules unable to internalize are less potent in guiding germ cells to the site where the gonad develops, thereby implicating chemokine receptor internalization in facilitating precision of migration during chemotaxis in vivo. We demonstrate that while CXCR4b activity positively regulates the duration of the active migration phases, the down-regulation of CXCR4b signalling by internalization limits the duration of this phase. This way, receptor signalling contributes to the persistence of germ cell migration, whereas receptor down-regulation enables the cells to stop and correct their migration path close to the target where germ cells encounter the highest chemokine signal. Chemokine receptors are involved in directing cell migration in different processes such as lymphocyte trafficking, cancer and in the development of the vascular system. The C-terminal domain of many chemokine receptors was shown to be essential for controlling receptor signalling and internalization. It would therefore be important to determine whether the role for receptor internalization in vivo as described here (allowing periodical corrections to the migration route) and the mechanisms involved (reducing the level of signalling) apply for those other events, too.

Das Einzugsgebiet der Fulda - Untersuchung der Methoden der Hochwasserstatistik im Zeichen des Klimawandels

Numerous studies have proven an effect of a probable climate change on the hydrosphere’s different subsystems. In the 21st century global and regional redistribution of water has to be expected and it is very likely that extreme weather phenomenon will occur more frequently. From a global view the flood situation will exacerbate. In contrast to these discoveries the classical approach of flood frequency analysis provides terms like “mean flood recurrence interval”. But for this analysis to be valid there is a need for the precondition of stationary distribution parameters which implies that the flood frequencies are constant in time. Newer approaches take into account extreme value distributions with time-dependent parameters. But the latter implies a discard of the mentioned old terminology that has been used up-to-date in engineering hydrology. On the regional scale climate change affects the hydrosphere in various ways. So, the question appears to be whether in central Europe the classical approach of flood frequency analysis is not usable anymore and whether the traditional terminology should be renewed. In the present case study hydro-meteorological time series of the Fulda catchment area (6930 km²), upstream of the gauging station Bonaforth, are analyzed for the time period 1960 to 2100. At first a distributed catchment area model (SWAT2005) is build up, calibrated and finally validated. The Edertal reservoir is regulated as well by a feedback control of the catchments output in case of low water. Due to this intricacy a special modeling strategy has been necessary: The study area is divided into three SWAT basin models and an additional physically-based reservoir model is developed. To further improve the streamflow predictions of the SWAT model, a correction by an artificial neural network (ANN) has been tested successfully which opens a new way to improve hydrological models. With this extension the calibration and validation of the SWAT model for the Fulda catchment area is improved significantly. After calibration of the model for the past 20th century observed streamflow, the SWAT model is driven by high resolution climate data of the regional model REMO using the IPCC scenarios A1B, A2, and B1, to generate future runoff time series for the 21th century for the various sub-basins in the study area. In a second step flood time series HQ(a) are derived from the 21st century runoff time series (scenarios A1B, A2, and B1). Then these flood projections are extensively tested with regard to stationarity, homogeneity and statistical independence. All these tests indicate that the SWAT-predicted 21st-century trends in the flood regime are not significant. Within the projected time the members of the flood time series are proven to be stationary and independent events. Hence, the classical stationary approach of flood frequency analysis can still be used within the Fulda catchment area, notwithstanding the fact that some regional climate change has been predicted using the IPCC scenarios. It should be noted, however, that the present results are not transferable to other catchment areas. Finally a new method is presented that enables the calculation of extreme flood statistics, even if the flood time series is non-stationary and also if the latter exhibits short- and longterm persistence. This method, which is called Flood Series Maximum Analysis here, enables the calculation of maximum design floods for a given risk- or safety level and time period.

Regional Labor Market Disparities

Regionale Arbeitsmärkte unterscheiden sich erheblich hinsichtlich wesentlicher Kennzahlen wie der Arbeitslosenquote, des Lohnniveaus oder der Beschäftigungsentwicklung. Wegen ihrer Persistenz sind diese Unterschiede von hoher Relevanz für die Politik. Die wirtschaftswissenschaftliche Literatur liefert bereits theoretische Modelle für die Analyse regionaler Arbeitsmärkte. In der Regel sind diese Modelle aber nicht dazu geeignet, regionale Arbeitsmarktunterschiede endogen zu erklären. Das bedeutet, dass sich die Unterschiede regionaler Arbeitsmärkte in der Regel nicht aus den Modellzusammenhängen selbst ergeben, sondern „von außen“ eingebracht werden müssen. Die empirische Literatur liefert Hinweise, dass die Unterschiede zwischen regionalen Arbeitsmärkten auf die Höhe der regionalen Arbeitsnachfrage zurückzuführen sind. Die Arbeitsnachfrage wiederum leitet sich aus den Gütermärkten ab: Es hängt von der Entwicklung der regionalen Gütermärkte ab, wie viele Arbeitskräfte benötigt werden. Daraus folgt, dass die Ursachen für Unterschiede regionaler Arbeitsmärkte in den Unterschieden zwischen den regionalen Gütermärkten zu suchen sind. Letztere werden durch die Literatur zur Neuen Ökonomischen Geographie (NÖG) untersucht. Die Literatur zur NÖG erklärt Unterschiede regionaler Gütermärkte, indem sie zentripetale und zentrifugale Kräfte gegenüberstellt. Zentripetale Kräfte sind solche, welche hin zur Agglomeration ökonomischer Aktivität wirken. Im Zentrum dieser Diskussion steht vor allem das Marktpotenzial: Unternehmen siedeln sich bevorzugt an solchen Standorten an, welche nahe an großen Märkten liegen. Erwerbspersonen wiederum bevorzugen solche Regionen, welche ihnen entsprechende Erwerbsaussichten bieten. Beides zusammen bildet einen sich selbst verstärkenden Prozess, der zur Agglomeration ökonomischer Aktivität führt. Dem stehen jedoch zentrifugale Kräfte gegenüber, welche eine gleichmäßigere Verteilung ökonomischer Aktivität bewirken. Diese entstehen beispielsweise durch immobile Produktionsfaktoren oder Ballungskosten wie etwa Umweltverschmutzung, Staus oder hohe Mietpreise. Sind die zentripetalen Kräfte hinreichend stark, so bilden sich Zentren heraus, in denen sich die ökonomische Aktivität konzentriert, während die Peripherie ausdünnt. In welchem Ausmaß dies geschieht, hängt von dem Verhältnis beider Kräfte ab. Üblicherweise konzentriert sich die Literatur zur NÖG auf Unterschiede zwischen regionalen Gütermärkten und geht von der Annahme perfekter Arbeitsmärkte ohne Arbeitslosigkeit aus. Die Entstehung und Persistenz regionaler Arbeitsmarktunterschiede kann die NÖG daher üblicherweise nicht erklären. An dieser Stelle setzt die Dissertation an. Sie erweitert die NÖG um Friktionen auf dem Arbeitsmarkt, um die Entstehung und Persistenz regionaler Arbeitsmarktunterschiede zu erklären. Sie greift dazu auf eine empirische Regelmäßigkeit zurück: Zahlreiche Studien belegen einen negativen Zusammenhang zwischen Lohn und Arbeitslosigkeit. In Regionen, in denen die Arbeitslosigkeit hoch ist, ist das Lohnniveau gering und umgekehrt. Dieser Zusammenhang wird als Lohnkurve bezeichnet. Auf regionaler Ebene lässt sich die Lohnkurve mithilfe der Effizienzlohntheorie erklären, die als theoretische Grundlage in der Dissertation Anwendung findet. Konzentriert sich nun die ökonomische Aktivität aufgrund der zentripetalen Kräfte in einer Region, so ist in diesem Zentrum die Arbeitsnachfrage höher. Damit befindet sich das Zentrum auf einer günstigen Position der Lohnkurve mit geringer Arbeitslosigkeit und hohem Lohnniveau. Umgekehrt findet sich die Peripherie auf einer ungünstigen Position mit hoher Arbeitslosigkeit und geringem Lohnniveau wieder. Allerdings kann sich die Lohnkurve in Abhängigkeit des Agglomerationsgrades verschieben. Das komplexe Zusammenspiel der endogenen Agglomeration mit den Arbeitsmarktfriktionen kann dann unterschiedliche Muster regionaler Arbeitsmarktdisparitäten hervorrufen. Die Dissertation zeigt auf, wie im Zusammenspiel der NÖG mit Effizienzlöhnen regionale Arbeitsmarktdisparitäten hervorgerufen werden. Es werden theoretische Modelle formuliert, die diese Interaktionen erklären und welche die bestehende Literatur durch spezifische Beiträge erweitern. Darüber hinaus werden die zentralen Argumente der Theorie einem empirischen Test unterworfen. Es kann gezeigt werden, dass das zentrale Argument – der positive Effekt des Marktpotentials auf die Arbeitsnachfrage – relevant ist. Außerdem werden Politikimplikationen abgeleitet und der weitere Forschungsbedarf aufgezeigt.

The Japanese Business System: Key Features and Prospects for Change

This paper argues that the Japanese business system cannot be adequately understood without extending the focus of analysis beyond the individual firm to the vertical keiretsu, or business group. The vertical group or keiretsu structure was first identified and studied in the auto and electronics industries, where it is most strongly marked, but it characterizes virtually all sectors, service industries as well as manufacturing. Large industrial vertical keiretsu are composed of subsidiaries engaged in three distinct types of activities (manufacturing, marketing, and quasirelated business). The coordination and control systems are built on the flows of products, financial resources, information and technology, and people across formal company boundaries, with the parent firm controlling the key flows. The paper examines the prevailing explanations first for the emergence and then for the persistence of the vertical group structure, and looks at the current pressures for change and adaptation in the system.

I Riflessi letterari dell’Unità d’Italia nella narrativa siciliana

El treball d'investigació té per objecte oferir un inventari raonat de novel•les i contes curts d’autors sicilians d’entre 1860 i 1898, de Giovanni Verga a la Simonetta Agnello Hornby, diferents en edat, cultura i condició social. Vol fer evident la persistència de la reflexió sobre el Risorgimento "traït", i ajudar a comprendre com hi havia un marc d’unitat política i institucional en el què no es donava cabuda a les diferències entre el Nord i el Sud d’Itàlia

Evaluación de la severidad de la ideación suicida autoinformada en escolares de 8 a 12 año = Assessment of self-report suicidal ideation severity in 8 to 12 years old school children

El objetivo de este estudio es la evaluación de la ideación suicida infantil y su severidad a partir de la información proporcionada por el propio niño. Para ello se ha aplicado el Children’s Depression Inventory a una muestra representativa de 361 escolares de edades comprendidas entre los 8 y 12 años. Un mes más tarde se ha verificado la persistencia de los deseos de morir mediante la Children’s Depression Rating Scale-Revised. Se evalúa la severidad de la ideación suicida autoinformada con relación a la persistencia, la alteración del estado de ánimo y el conocimiento intelectual de la muerte. Los resultados indican que la persistencia de la intencionalidad suicida esta asociada a una mayor sintomatología depresiva