The Western literary messenger.

Published: Buffalo [N.Y.] : Thomas & Lathrop, Sept. 1854-

The Western messenger.

Editors: Nov. 1837-Oct. 1839, J.F. Clarke (May-Oct. 1839 assisted by W.H. Channing and J.H. Perkins.

The Dairy messenger.

Mode of access: Internet.

Illinois health messenger.

None published: 1954-1955.

The mégha dúta, or, cloud messenger : a poem, in the Sanscrit language /

Translation of: Meghadūta.

Dissertations on the regenerate life ; in harmony with the theological views of Baron Swedenborg, the undoubted messenger of our Lord's second advent. To which is prefixed, A short account of the life of Baron Swedenborg.

Includes bibliographical references.

Dissertations on the regenerate life ; in harmony with the theological views of Emanuel Swedenborg, the undoubted messenger of our Lord's second advent /

Mode of access: Internet.

An abstract of the most important alterations, of general interest, introduced by the Revised statutes [New York]; the principal part of which originally appeared in numbers published in the Ontario messenger;

Mode of access: Internet.

The Christian messenger : devoted to the doctrine of universal benevolence--the defense of liberal principles generally in religion, and miscellaneous reading of chaste and moral tendency.

Vol. 1, no. 1 is dated Oct. 29, 1831.

The messenger of song. Contains a graded course for singing classes and day schools; also solos, duetts, quartetts, glees and choruses for musical conventions, musical institutes, etc., etc.

Mode of access: Internet.

Southern literary messenger; devoted to every department of literature and the fine arts.

Numbering irregular during 1862-63.

Steatosis in chronic hepatitis C: Association with increased messenger RNA expression of collagen I, tumor necrosis factor-α and cytochrome P450 2E1

Background: Increased levels of tumor necrosis factor (TNF)-alpha and oxidative stress have been implicated as factors contributing to hepatic injury in fatty liver diseases. As steatosis is associated with an accelerated progression of fibrosis in chronic hepatitis C (HCV), we hypothesized that the messenger (m)RNA expression of genes involved with the production of reactive oxygen species, inflammation and cellular injury would be increased in liver tissue from subjects with steatosis and chronic HCV. Methods: Real-time polymerase chain reaction was performed to determine relative mRNA expression levels of collagen I, TNF-alpha, cytochrome P450 2E1 (CYP 2E1), transforming growth factor-beta1 and CD14 in liver biopsies from 38 patients with chronic HCV. The mRNA expression levels were compared between subjects with and without steatosis, fibrosis, and inflammation. Results: Multivariate analysis demonstrated that collagen I mRNA expression was increased by 199% in steatosis (P = 0.02), 85% in moderate to severe fibrosis (P = 0.02) and 157% in inflammation (P = 0.03). Livers of patients with steatosis also had an increase in TNF-alpha mRNA expression by 50% (P = 0.03) and CYP 2E1 expression by 37% (P = 0.04) compared with non-steatotic livers. Tumor necrosis factor-alpha protein was localized to Kupffer cells, bile ducts and portal inflammatory cells by immunohistochemistry. Conclusion: Increased expression of TNF-alpha may be involved in the pathogenesis of liver injury and progression of fibrosis in individuals who have steatosis in association with chronic HCV. (C) 2003 Blackwell Publishing Asia Pty Ltd.

Pseudo-messenger RNA: Phantoms of the transcriptome

The mammalian transcriptome harbours shadowy entities that resist classification and analysis. In analogy with pseudogenes, we define pseudo-messenger RNA to be RNA molecules that resemble protein- coding mRNA, but cannot encode full-length proteins owing to disruptions of the reading frame. Using a rigorous computational pipeline, which rules out sequencing errors, we identify 10,679 pseudo - messenger RNAs ( approximately half of which are transposonassociated) among the 102,801 FANTOM3 mouse cDNAs: just over 10% of the FANTOM3 transcriptome. These comprise not only transcribed pseudogenes, but also disrupted splice variants of otherwise protein- coding genes. Some may encode truncated proteins, only a minority of which appear subject to nonsense- mediated decay. The presence of an excess of transcripts whose only disruptions are opal stop codons suggests that there are more selenoproteins than currently estimated. We also describe compensatory frameshifts, where a segment of the gene has changed frame but remains translatable. In summary, we survey a large class of non- standard but potentially functional transcripts that are likely to encode genetic information and effect biological processes in novel ways. Many of these transcripts do not correspond cleanly to any identifiable object in the genome, implying fundamental limits to the goal of annotating all functional elements at the genome sequence level.